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CRH gene expression is repressed by MECP2
Stable Identifier
R-HSA-9017988
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates transcription of neuronal ligands (Homo sapiens)
CRH gene expression is repressed by MECP2 (Homo sapiens)
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Based on studies in mice, MECP2 represses transcription from the CRH gene promoter (McGill et al. 2006). Mice with the loss of function of Mecp2 exhibit overexpression of Crh (McGill et al. 2006). Surprisingly, mice with Mecp2 gene duplication, which serve as a model for the MECP2 duplication syndrome, also overexpress Crh (Samaco et al. 2012).
Participants
Input
CRH gene [nucleoplasm]
(Homo sapiens)
Output
CRH [extracellular region]
(Homo sapiens)
Participates
as an event of
MECP2 regulates transcription of neuronal ligands (Homo sapiens)
This event is regulated
Negatively by
Regulator
MECP2:CRH gene [nucleoplasm]
(Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Crh gene expression is repressed by Mecp2 (Mus musculus)
Authored
Orlic-Milacic, M (2017-10-02)
Reviewed
Krishnaraj, R (2018-08-07)
Christodoulou, J (2018-08-07)
Created
Orlic-Milacic, M (2017-08-29)
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