CRH gene expression is repressed by MECP2

Stable Identifier
R-HSA-9017988
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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CRH gene expression is repressed by MECP2
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Based on studies in mice, MECP2 represses transcription from the CRH gene promoter (McGill et al. 2006). Mice with the loss of function of Mecp2 exhibit overexpression of Crh (McGill et al. 2006). Surprisingly, mice with Mecp2 gene duplication, which serve as a model for the MECP2 duplication syndrome, also overexpress Crh (Samaco et al. 2012).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:CRH gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Inferred From
Crh gene expression is repressed by Mecp2 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-08-29)
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