Reactome | Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

Stable Identifier

R-HSA-9021601

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

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Plasma-membrane localized estrogen receptors interact with and signal through heterotrimeric G-proteins (Wyckoff et al, 2001). The estrogen receptor makes direct interactions with both the G alpha i and the G beta gamma proteins and these interactions are required for downstream signaling to SRC, which is required for signaling through MAPK and PI3K/AKT, as well as for activation of eNOS activity in endothelial cells (Castoria et al, 2001; Wyckoff et al, 2001). Estrogen-stimulation promotes dimerization of the estrogen receptor and dissociation of the heteromeric G-protein (reviewed in Levin, 2015; Schwartz et al, 2016)

Literature References

PubMed ID	Title	Journal	Year
11369763	Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i) Mendelsohn, ME, Yuhanna, IS, Mumby, SM, Mineo, C, Wyckoff, MH, Chambliss, KL, Shaul, PW	J. Biol. Chem.	2001
25587652	Extranuclear steroid receptors are essential for steroid hormone actions Levin, ER	Annu. Rev. Med.	2015
27288742	Rapid steroid hormone actions via membrane receptors Verma, A, Schwartz, Z, Bivens, CB, Schwartz, N, Boyan, BD	Biochim. Biophys. Acta	2016
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	EMBO J.	2001