Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG

Stable Identifier
R-HSA-9021601
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Plasma-membrane localized estrogen receptors interact with and signal through heterotrimeric G-proteins (Wyckoff et al, 2001). The estrogen receptor makes direct interactions with both the G alpha i and the G beta gamma proteins and these interactions are required for downstream signaling to SRC, which is required for signaling through MAPK and PI3K/AKT, as well as for activation of eNOS activity in endothelial cells (Castoria et al, 2001; Wyckoff et al, 2001). Estrogen-stimulation promotes dimerization of the estrogen receptor and dissociation of the heteromeric G-protein (reviewed in Levin, 2015; Schwartz et al, 2016)

Literature References
PubMed ID Title Journal Year
25587652 Extranuclear steroid receptors are essential for steroid hormone actions

Levin, ER

Annu. Rev. Med. 2015
11369763 Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i)

Wyckoff, MH, Chambliss, KL, Mineo, C, Yuhanna, IS, Mendelsohn, ME, Mumby, SM, Shaul, PW

J. Biol. Chem. 2001
27288742 Rapid steroid hormone actions via membrane receptors

Schwartz, N, Verma, A, Bivens, CB, Schwartz, Z, Boyan, BD

Biochim. Biophys. Acta 2016
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F

EMBO J. 2001
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