Reactome | G-proteins dissociate from plasma-membrane estrogen receptors

G-proteins dissociate from plasma-membrane estrogen receptors

Stable Identifier

R-HSA-9021600

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane

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G-proteins dissociate from plasma-membrane estrogen receptors

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Estrogen-stimulation promotes dissociation of the G protein subunits and stimulates downstream signaling through SRC and PI3K (Castoria et al, 2001; Castoria et al, 2012; Wyckoff et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
22266855	Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells Castoria, G, Giovannelli, P, Lombardi, M, De Rosa, C, Giraldi, T, de Falco, A, Barone, MV, Abbondanza, C, Migliaccio, A, Auricchio, F	Oncogene	2012
11369763	Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i) Wyckoff, MH, Chambliss, KL, Mineo, C, Yuhanna, IS, Mendelsohn, ME, Mumby, SM, Shaul, PW	J. Biol. Chem.	2001
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F	EMBO J.	2001