OPRM1 gene expression is repressed by MECP2

Stable Identifier
R-HSA-9017921
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, association of MECP2 with the hypermethylated OPRM1 gene promoter, encoding Mu-type opioid receptor (MOR), correlates with transcriptional repression of OPRM1 in the cerebellum. MECP2-mediated transcriptional repression of OPRM1 may be relieved by interaction of MECP2 with SMARCA4 (BRG1), a component of the chromatin remodeling SWI/SNF complex (Hwang et al. 2009). MECP2-mediated repression of OPRM1 involves the SIN3A co-repressor complex (Hwang et al. 2010). In the mouse model of MECP2 duplication syndrome, OPRM1 transcription in the amygdala and hippocampus is increased compared to wild-type mice (Samaco et al. 2012).

Participants
Participant Of
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!