Oprm1 gene expression is repressed by Mecp2

Stable Identifier
Reaction [omitted]
Mus musculus
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Oprm1 gene expression is repressed by Mecp2

Binding of Mecp2, in association with the Sin3a co-repressor complex, to the hypermethylated promoter of the Oprm1 gene, encoding Mu-type opioid receptor (MOR), correlates with transcriptional repression of Oprm1 in the cerebellum (Hwang et al. 2009. Hwang et al. 2010). In the mouse model of the Mecp2 duplication syndrome, transcription of the Oprm1 gene in the amygdala and hippocampus is increased compared to wild type mice (Samaco et al. 2012).

Literature References
PubMed ID Title Journal Year
19602036 Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor

Hwang, CK, Song, KY, Kim, CS, Choi, HS, Guo, XH, Law, PY, Wei, LN, Loh, HH

J. Cell. Mol. Med. 2009
22231481 Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Samaco, RC, Mandel-Brehm, C, McGraw, CM, Shaw, CA, McGill, BE, Zoghbi, HY

Nat. Genet. 2012
20385708 Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells

Hwang, CK, Kim, CS, Kim, DK, Law, PY, Wei, LN, Loh, HH

Mol. Pharmacol. 2010
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