MECP2 regulates neuronal receptors and channels

Stable Identifier
R-HSA-9022699
Type
Pathway
Species
Homo sapiens
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Receptors directly transcriptionally regulated by MECP2 include glutamate receptor GRIA2 (Qiu et al. 2012), NMDA receptor subunits GRIN2A (Durand et al. 2012) and GRIN2B (Lee et al. 2008), opioid receptors OPRK1 (Chahrour et al. 2008) and OPRM1 (Hwang et al. 2009, Hwang et al. 2010, Samaco et al. 2012), GPRIN1 (Chahrour et al. 2008), MET (Plummer et al. 2013), and NOTCH1 (Li et al. 2014). Channels/transporters regulated by MECP2 include TRPC3 (Li et al. 2012) and SLC2A3 (Chen et al. 2013). MECP2 also regulates transcription of FKBP5, involved in trafficking of glucocorticoid receptors (Nuber et al. 2005, Urdinguio et al. 2008) and is implicated in regulation of expression of SEMA3F (semaphorin 3F) in mouse olfactory neurons (Degano et al. 2009). In zebrafish, Mecp2 is implicated in sensory axon guidance by direct stimulation of transcription of Sema5b and Robo2 (Leong et al. 2015). MECP2 may indirectly regulate signaling by neuronal receptor tyrosine kinases by regulating transcription of protein tyrosine phosphatases, PTPN1 (Krishnan et al. 2015) and PTPN4 (Williamson et al. 2015).

Literature References
PubMed ID Title Journal Year
16002417 Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome

Guy, J, Nuber, UA, Roloff, TC, Bird, A, Lipkowitz, B, Selfridge, J, Ropers, HH, Holmes, MC, Steinhoff, C, Schulz, R, Kriaucionis, S

Hum. Mol. Genet. 2005
22262897 The Rett syndrome protein MeCP2 regulates synaptic scaling

Ghosh, A, Qiu, Z, Zhang, Y, Liu, XY, Lieberman, DN, Sylwestrak, EL

J. Neurosci. 2012
20385708 Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells

Loh, HH, Wei, LN, Kim, DK, Law, PY, Kim, CS, Hwang, CK

Mol. Pharmacol. 2010
25424712 Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

Pelka, GJ, Ellaway, CJ, Williamson, SL, Tam, PP, Peters, GB, Christodoulou, J

Eur. J. Hum. Genet. 2015
18511691 MeCP2, a key contributor to neurological disease, activates and represses transcription

Qin, J, Jung, SY, Wong, ST, Zoghbi, HY, Shaw, C, Chahrour, M, Zhou, X

Science 2008
23259945 NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2

Patrizi, A, Quast, KB, Hensch, TK, Pavlyuk, R, Fagiolini, M, Carninci, P, Saxena, A, Durand, S, Hachigian, L

Neuron 2012
23027959 Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice

Pozzo-Miller, L, Larimore, J, Li, W, Calfa, G

Proc. Natl. Acad. Sci. U.S.A. 2012
26214522 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Connors, CR, Krishnan, K, Shea, SD, Krishnan, N, Tonks, NK, Van Aelst, L, Choy, MS, Peti, W, Page, R

J. Clin. Invest. 2015
23493374 Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression

Thamotharan, S, Chen, Y, Devaskar, SU, Shin, BC

Endocrinology 2013
19602036 Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor

Choi, HS, Loh, HH, Song, KY, Wei, LN, Guo, XH, Law, PY, Kim, CS, Hwang, CK

J. Cell. Mol. Med. 2009
19628041 MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function

Pasterkamp, RJ, Ronnett, GV, Degano, AL

Mol. Cell. Neurosci. 2009
18989361 Mecp2-null mice provide new neuronal targets for Rett syndrome

Diaz-Uriarte, R, Fernandez, AF, Lopez-Serra, L, Lopez-Nieva, P, Urdinguio, RG, Esteller, M, Alaminos, M

PLoS ONE 2008
18952054 Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation

Lee, S, Kim, W, Yoon, BJ, Ham, BJ, Bear, MF, Chen, W

Biochem. Biophys. Res. Commun. 2008
24150225 Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

Bergman, MY, Evgrafov, OV, Plummer, JT, Aldinger, KA, Friez, M, Haiman, CA, Levitt, P

Transl Psychiatry 2013
25420914 Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

Zhong, X, Jin, P, Chau, KF, Masliah, J, Kong, G, Chi, J, Santistevan, NJ, Kadakia, M, Zhang, J, Guo, W, Li, H, Li, X, Chang, Q, Zhao, X

Nat Commun 2014
26733807 Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2

Lim, ZH, Leong, WY, Goh, EL, Pietri, T, Korzh, V

Front Cell Neurosci 2015
22231481 Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Mandel-Brehm, C, Samaco, RC, Zoghbi, HY, McGill, BE, Shaw, CA, McGraw, CM

Nat. Genet. 2012
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