Estrogen-responsive GREB1 gene transcription

Stable Identifier
R-HSA-9011950
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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Estrogen-responsive GREB1 gene transcription
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GREB1 is transcribed in response to estrogen stimulation in a manner that depends on NCOA3, ZNF217 and KDM4B (Ghosh et al, 2000; Rae et al, 2005; Sun et al, 2007; Kawazu et al, 2011; Nguyen et al, 2014). Estrogen-responsive transcription is directed by three EREs at -21.2, -9.5 and -1.6kb relative to the transcription start site and may be facilitated by the formation of chromatin loops (Lin et al, 2004; Sun et al, 2007; Deschenes et al, 2007; Lin et al, 2007).

Literature References
PubMed ID Title Journal Year
15345050 Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells

Lin, CY, Ström, A, Vega, VB, Kong, SL, Yeo, AL, Thomsen, JS, Chan, WC, Doray, B, Bangarusamy, DK, Ramasamy, A, Vergara, LA, Tang, S, Chong, A, Bajic, VB, Miller, LD, Gustafsson, JA, Liu, ET

Genome Biol. 2004
24973012 A functional interplay between ZNF217 and estrogen receptor alpha exists in luminal breast cancers

Nguyen, NT, Vendrell, JA, Poulard, C, Győrffy, B, Goddard-Léon, S, Bièche, I, Corbo, L, Le Romancer, M, Bachelot, T, Treilleux, I, Cohen, PA

Mol Oncol 2014
15986123 GREB 1 is a critical regulator of hormone dependent breast cancer growth

Rae, JM, Johnson, MD, Scheys, JO, Cordero, KE, Larios, JM, Lippman, ME

Breast Cancer Res. Treat. 2005
11103799 PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer

Ghosh, MG, Thompson, DA, Weigel, RJ

Cancer Res. 2000
17666587 Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells

Sun, J, Nawaz, Z, Slingerland, JM

Mol. Endocrinol. 2007
17510434 Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer

Lin, Z, Reierstad, S, Huang, CC, Bulun, SE

Cancer Res. 2007
17463000 Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences

Deschênes, J, Bourdeau, V, White, JH, Mader, S

J. Biol. Chem. 2007
21445275 Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

Kawazu, M, Saso, K, Tong, KI, McQuire, T, Goto, K, Son, DO, Wakeham, A, Miyagishi, M, Mak, TW, Okada, H

PLoS ONE 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Homo sapiens)
Active Unit
ESR1 dimer:ESTG [nucleoplasm]
Authored
Rothfels, K  (2017-09-29)
Reviewed
Magnani, L  (2018-02-23)
Created
Rothfels, K  (2017-07-07)
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