Reactome | Estrogen-responsive GREB1 gene transcription

Estrogen-responsive GREB1 gene transcription

Stable Identifier

R-HSA-9011950

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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Estrogen-responsive GREB1 gene transcription

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GREB1 is transcribed in response to estrogen stimulation in a manner that depends on NCOA3, ZNF217 and KDM4B (Ghosh et al, 2000; Rae et al, 2005; Sun et al, 2007; Kawazu et al, 2011; Nguyen et al, 2014). Estrogen-responsive transcription is directed by three EREs at -21.2, -9.5 and -1.6kb relative to the transcription start site and may be facilitated by the formation of chromatin loops (Lin et al, 2004; Sun et al, 2007; Deschenes et al, 2007; Lin et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
15345050	Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells Lin, CY, Ström, A, Vega, VB, Kong, SL, Yeo, AL, Thomsen, JS, Chan, WC, Doray, B, Bangarusamy, DK, Ramasamy, A, Vergara, LA, Tang, S, Chong, A, Bajic, VB, Miller, LD, Gustafsson, JA, Liu, ET	Genome Biol.	2004
24973012	A functional interplay between ZNF217 and estrogen receptor alpha exists in luminal breast cancers Nguyen, NT, Vendrell, JA, Poulard, C, Győrffy, B, Goddard-Léon, S, Bièche, I, Corbo, L, Le Romancer, M, Bachelot, T, Treilleux, I, Cohen, PA	Mol Oncol	2014
15986123	GREB 1 is a critical regulator of hormone dependent breast cancer growth Rae, JM, Johnson, MD, Scheys, JO, Cordero, KE, Larios, JM, Lippman, ME	Breast Cancer Res. Treat.	2005
11103799	PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer Ghosh, MG, Thompson, DA, Weigel, RJ	Cancer Res.	2000
17666587	Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells Sun, J, Nawaz, Z, Slingerland, JM	Mol. Endocrinol.	2007
17510434	Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer Lin, Z, Reierstad, S, Huang, CC, Bulun, SE	Cancer Res.	2007
17463000	Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences Deschênes, J, Bourdeau, V, White, JH, Mader, S	J. Biol. Chem.	2007
21445275	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development Kawazu, M, Saso, K, Tong, KI, McQuire, T, Goto, K, Son, DO, Wakeham, A, Miyagishi, M, Mak, TW, Okada, H	PLoS ONE	2011