Regulation of PTEN localization

Stable Identifier
Homo sapiens
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When monoubiquitinated by E3 ubiquitin ligases XIAP and NEDD4, PTEN translocates from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009). USP7 (HAUSP)-mediated deubiquitination of monoubiquitinated nuclear PTEN promotes relocalization of PTEN to the cytosol (Song et al. 2008).

Literature References
PubMed ID Title Journal Year
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Parent, S, Leblanc, V, Asselin, E

J. Biol. Chem. 2009
17218261 Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, LC, Wang, X, Carver, BS, Jiang, X, Pavletich, NP, Tempst, P, Erdjument-Bromage, H, Teruya-Feldstein, J, Pandolfi, PP, Misteli, T, Cordon-Cardo, C, Chen, Z, Kim, HJ, Chi, SG, Yang, H, Alimonti, A

Cell 2007
18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Pandolfi, PP, Carracedo, A, Egia, A, Song, MS, Teruya-Feldstein, J, Lo-Coco, F, Salmena, L

Nature 2008
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