Regulation of PTEN localization

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R-HSA-8948747
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Pathway
Species
Homo sapiens
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When monoubiquitinated by E3 ubiquitin ligases XIAP and NEDD4, PTEN translocates from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009). USP7 (HAUSP)-mediated deubiquitination of monoubiquitinated nuclear PTEN promotes relocalization of PTEN to the cytosol (Song et al. 2008).

Literature References
PubMed ID Title Journal Year
17218261 Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, LC, Wang, X, Alimonti, A, Chen, Z, Teruya-Feldstein, J, Yang, H, Pavletich, NP, Carver, BS, Cordon-Cardo, C, Erdjument-Bromage, H, Tempst, P, Chi, SG, Kim, HJ, Misteli, T, Jiang, X, Pandolfi, PP

Cell 2007
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Leblanc, V, Parent, S, Asselin, E

J. Biol. Chem. 2009
18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Song, MS, Salmena, L, Carracedo, A, Egia, A, Lo-Coco, F, Teruya-Feldstein, J, Pandolfi, PP

Nature 2008
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