Reactome | Regulation of PTEN localization

Regulation of PTEN localization

Stable Identifier

R-HSA-8948747

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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When monoubiquitinated by E3 ubiquitin ligases XIAP and NEDD4, PTEN translocates from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009). USP7 (HAUSP)-mediated deubiquitination of monoubiquitinated nuclear PTEN promotes relocalization of PTEN to the cytosol (Song et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
19473982	X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization Van Themsche, C, Parent, S, Leblanc, V, Asselin, E	J. Biol. Chem.	2009
17218261	Ubiquitination regulates PTEN nuclear import and tumor suppression Trotman, LC, Wang, X, Carver, BS, Jiang, X, Pavletich, NP, Tempst, P, Erdjument-Bromage, H, Teruya-Feldstein, J, Pandolfi, PP, Misteli, T, Cordon-Cardo, C, Chen, Z, Kim, HJ, Chi, SG, Yang, H, Alimonti, A	Cell	2007
18716620	The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network Pandolfi, PP, Carracedo, A, Egia, A, Song, MS, Teruya-Feldstein, J, Lo-Coco, F, Salmena, L	Nature	2008