PTEN undergoes monoubiquitination

Stable Identifier
R-HSA-6807106
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

When present at low levels in the cell, the E3 ubiquitin ligase XIAP monoubiquitinates PTEN (Van Themsche et al. 2009). NEDD4 (NEDD4-1) can also monoubiquitinate PTEN (Trotman et al. 2007). Monoubiquitination of PTEN on at least lysine residues K13 and K289 causes translocation of PTEN from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009).

Literature References
PubMed ID Title Journal Year
17218261 Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, LC, Wang, X, Alimonti, A, Chen, Z, Teruya-Feldstein, J, Yang, H, Pavletich, NP, Carver, BS, Cordon-Cardo, C, Erdjument-Bromage, H, Tempst, P, Chi, SG, Kim, HJ, Misteli, T, Jiang, X, Pandolfi, PP

Cell 2007
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Leblanc, V, Parent, S, Asselin, E

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of XIAP,NEDD4 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed