USP7 (HAUSP) deubiquitinates monoubiquitinated nuclear PTEN, thus promoting relocalization of PTEN to the cytosol. USP7-mediated deubiquitination of PTEN is negatively regulated by PML in the presence of DAXX, but the exact mechanism has not been elucidated (Song et al. 2008).
Pandolfi, PP, Carracedo, A, Egia, A, Song, MS, Teruya-Feldstein, J, Lo-Coco, F, Salmena, L
cysteine-type deubiquitinase activity of USP7 [nucleoplasm]
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