USP7 deubiquitinates monoubiquitinated PTEN

Stable Identifier
R-HSA-6807118
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP7 deubiquitinates monoubiquitinated PTEN
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USP7 (HAUSP) deubiquitinates monoubiquitinated nuclear PTEN, thus promoting relocalization of PTEN to the cytosol. USP7-mediated deubiquitination of PTEN is negatively regulated by PML in the presence of DAXX, but the exact mechanism has not been elucidated (Song et al. 2008).
Literature References
PubMed ID Title Journal Year
18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Song, MS, Salmena, L, Carracedo, A, Egia, A, Lo-Coco, F, Teruya-Feldstein, J, Pandolfi, PP

Nature 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type deubiquitinase activity of USP7 [nucleoplasm]

Physical Entity
USP7 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
This event is regulated
Negatively by
Regulator
PML [nucleoplasm] (Homo sapiens)
Orthologous Events
USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)
USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)
USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)
USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)
USP7 deubiquitinates monoubiquitinated PTEN (Gallus gallus)
USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)
USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)
USP7 deubiquitinates monoubiquitinated PTEN (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-29)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Created
Orlic-Milacic, M  (2015-10-29)
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