USP7 deubiquitinates monoubiquitinated PTEN

Stable Identifier
R-HSA-6807118
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP7 (HAUSP) deubiquitinates monoubiquitinated nuclear PTEN, thus promoting relocalization of PTEN to the cytosol. USP7-mediated deubiquitination of PTEN is negatively regulated by PML in the presence of DAXX, but the exact mechanism has not been elucidated (Song et al. 2008).

Literature References
PubMed ID Title Journal Year
18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Song, MS, Salmena, L, Carracedo, A, Egia, A, Lo-Coco, F, Teruya-Feldstein, J, Pandolfi, PP

Nature 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP7 [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created