Monoubiquitinated PTEN translocates to the nucleus

Stable Identifier
R-HSA-6807105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Monoubiquitinated PTEN translocates to the nucleus. Lysine residues K13 and K289 of PTEN are important monoubiquitination targets and their mutation abrogates PTEN nuclear localization (Trotman et al. 2007).

Literature References
PubMed ID Title Journal Year
17218261 Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, LC, Wang, X, Alimonti, A, Chen, Z, Teruya-Feldstein, J, Yang, H, Pavletich, NP, Carver, BS, Cordon-Cardo, C, Erdjument-Bromage, H, Tempst, P, Chi, SG, Kim, HJ, Misteli, T, Jiang, X, Pandolfi, PP

Cell 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created