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MECOM [nucleoplasm]
Stable Identifier
R-HSA-8943897
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MDS1 and EVI1 complex locus protein EVI1, EVI1_HUMAN, PRDM3, KMT8E
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03112 MECOM
Gene Names
MECOM, EVI1, MDS1, PRDM3
Chain
chain:1-1230
Reference Genes
BioGPS Gene:2122 MECOM
COSMIC (genes):MECOM MECOM
CTD Gene:2122 MECOM
dbSNP Gene:2122 MECOM
ENSEMBL:ENSG00000085276 MECOM
HGNC:3498 MECOM
KEGG Gene (Homo sapiens):2122 MECOM
Monarch:2122 MECOM
NCBI Gene:2122 MECOM
OMIM:165215 MECOM
OMIM:600049 MECOM
UCSC:Q03112 MECOM
Reference Transcript
RefSeq:XM_005247215.3 MECOM
RefSeq:NM_001105078.3 MECOM
RefSeq:NM_001163999.1 MECOM
RefSeq:XM_005247221.2 MECOM
RefSeq:XM_017005875.1 MECOM
RefSeq:XM_017005876.1 MECOM
RefSeq:NM_001105077.3 MECOM
RefSeq:NM_004991.3 MECOM
RefSeq:NM_005241.3 MECOM
RefSeq:XM_005247223.2 MECOM
RefSeq:XM_017005874.1 MECOM
RefSeq:NM_001205194.1 MECOM
RefSeq:NM_001164000.1 MECOM
Other Identifiers
0006860093
11727645_a_at
11734506_a_at
11734507_s_at
16961331
1881_at
1882_g_at
2122
221884_at
226420_at
2704442
2704443
2704444
2704448
2704449
2704451
2704453
2704456
2704457
2704460
2704461
2704463
2704464
2704468
2704469
2704472
2704473
2704474
2704482
2704483
2704489
2704490
2704491
2704492
2704493
2704531
2704532
2704533
2704599
2704600
46205_at
59145_at
8091972
8091991
A_23_P212688
A_23_P317324
A_24_P15154
A_24_P153490
A_24_P320103
A_33_P3888629
GE59162
GE629408
GE88841
GO:0000118
GO:0002376
GO:0003674
GO:0003676
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006915
GO:0006950
GO:0007049
GO:0007165
GO:0007275
GO:0008150
GO:0008168
GO:0008219
GO:0008283
GO:0009058
GO:0010468
GO:0016607
GO:0016740
GO:0030154
GO:0032259
GO:0032991
GO:0034641
GO:0043069
GO:0043167
GO:0043226
GO:0045892
GO:0045893
GO:0046329
GO:0046872
GO:0046974
GO:0048856
GO:0051276
GO:0051567
GO:0051726
GO:0070828
GO:0071425
Hs.234773.0.S1_3p_at
Hs.234773.0.S2_3p_at
ILMN_1803367
ILMN_3307897
PH_hs_0035989
Participant Of
input
MECOM (EVI1) binds the PTEN gene promoter
hasComponent
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm]
MECOM:PTEN gene [nucleoplasm]
Other forms of this molecule
MECOM [cytosol]
Inferred To
pdpr [nucleoplasm] (Xenopus tropicalis)
ADR1 [nucleoplasm] (Saccharomyces cerevisiae)
MECOM [nucleoplasm] (Bos taurus)
MECOM [nucleoplasm] (Caenorhabditis elegans)
MECOM [nucleoplasm] (Canis familiaris)
MECOM [nucleoplasm] (Gallus gallus)
MECOM [nucleoplasm] (Sus scrofa)
Mecom [nucleoplasm] (Mus musculus)
Mecom [nucleoplasm] (Rattus norvegicus)
LOC101885450 [nucleoplasm] (Danio rerio)
sfc2 [nucleoplasm] (Schizosaccharomyces pombe)
Dmel\CG10348 [nucleoplasm] (Drosophila melanogaster)
ham [nucleoplasm] (Drosophila melanogaster)
si:ch211-263k4.2 [nucleoplasm] (Danio rerio)
Dmel\CG7691 [nucleoplasm] (Drosophila melanogaster)
mecom [nucleoplasm] (Danio rerio)
mecom [nucleoplasm] (Xenopus tropicalis)
Homologues of MECOM [nucleoplasm] (Danio rerio)
Homologues of MECOM [nucleoplasm] (Drosophila melanogaster)
Homologues of MECOM [nucleoplasm] (Schizosaccharomyces pombe)
Homologues of MECOM [nucleoplasm] (Xenopus tropicalis)
prz1 [nucleoplasm] (Schizosaccharomyces pombe)
Cross References
RefSeq
XP_016861363.1
,
XP_005247278.1
,
NP_001098547.3
,
NP_005232.2
,
NP_001098548.2
,
XP_005247280.1
,
NP_004982.2
,
XP_016861365.1
,
XP_005247272.1
,
NP_001192123.1
,
NP_001157471.1
,
XP_016861364.1
,
NP_001157472.1
OpenTargets
ENSG00000085276
HPA
ENSG00000085276-MECOM
GeneCards
Q03112
Ensembl
ENST00000628990
,
ENST00000464456
,
ENSP00000419770
,
ENSP00000498411
,
ENSP00000264674
,
ENST00000651503
,
ENST00000468789
,
ENSP00000417899
,
ENST00000264674
,
ENSP00000419995
,
ENST00000494292
,
ENSP00000486104
,
ENSG00000085276
PRO
Q03112
Orphanet
17464
PDB
6BW3
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.645
4
UniProt:P56546
1
Ctbp2 [nucleoplasm]
(R-MMU-5333990)
0.635
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.593
5
UniProt:Q5R372-2 RABGAP1L
0.57
3
UniProt:P01100 FOS
2
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
FOS [nucleoplasm]
(R-HSA-450216)
0.499
4
UniProt:Q92569 PIK3R3
2
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
PIK3R3 [cytosol]
(R-HSA-205223)
0.488
2
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