Reactome | MECOM [cytosol]

MECOM [cytosol]

Stable Identifier

R-HSA-5634790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MDS1 and EVI1 complex locus protein EVI1, EVI1_HUMAN, PRDM3, KMT8E

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03112 MECOM

Gene Names

MECOM, EVI1, MDS1, PRDM3

Chain

chain:1-1230

Reference Genes

BioGPS Gene:2122 Q031129

COSMIC (genes):MECOM MECOM

CTD Gene:2122 Q031129

dbSNP Gene:2122 Q031129

ENSEMBL:ENSG00000085276 MECOM

HGNC:3498 Q031129

KEGG:hsa:2122 Q031129

Monarch:2122 Q031129

NCBI Gene:2122 Q031129

OMIM:165215 Q031129

OMIM:600049 Q031129

UCSC:Q03112 Q031129

Reference Transcript

Participates

as a member of

PRDM16, MECOM [cytosol] (Homo sapiens)

Other forms of this molecule

MECOM [nucleoplasm]

Inferred To

egl-43 [cytosol] (Caenorhabditis elegans)

Homologues of MECOM [cytosol] (Schizosaccharomyces pombe)

MECOM [cytosol] (Canis familiaris)

MECOM [cytosol] (Sus scrofa)

sfc2 [cytosol] (Schizosaccharomyces pombe)

prz1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_005247280.1, NP_001192123.1, XP_005247276.1, NP_005232.2, XP_016861363.1, XP_005247272.1, XP_016861364.1, NP_001157472.1, NP_001157471.1, XP_005247277.1, XP_005247278.1, XP_016861365.1, NP_004982.2, NP_001098548.2, NP_001098547.3

OpenTargets

ENSG00000085276

ENSEMBL

ENST00000494292, ENST00000264674, ENSP00000264674, ENSP00000419770, ENSP00000498411, ENST00000468789, ENST00000651503, ENST00000464456, ENSP00000419995, ENSP00000417899, ENST00000628990, ENSG00000085276, ENSP00000486104

HPA

ENSG00000085276-MECOM

GeneCards

MECOM

PRO

Q03112

Pharos - Targets

Q03112

Orphanet

MECOM

GlyGen

Q03112

PDB

6BW3

HMDB Protein

HMDBP14555

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.645	4
UniProt:P56546 Ctbp2	1	CTBP2 [nucleoplasm] (R-MMU-5333990)	0.635	3
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.615	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.593	5
UniProt:Q5R372-2 RABGAP1L			0.57	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.499	4
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2

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