Reactome | Expression of Perm1

Expression of Perm1

Stable Identifier

R-MMU-8940300

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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The Perm1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The Perm1 gene is expressed selectively in muscle where it is activated by Ppargc1a via the estrogen receptor Esrra, which binds regulatory elements in the first intron of the Perm1 gene (Cho et al. 2013). Perm1 expression in adult skeletal muscle promotes mitochondrial biogenesis, oxidative capacity and vascularization, without affecting fiber type switching (Cho et al. 2016). Expression of Perm1 is activated by exercise (Cho et al. 2013, 2016).

Literature References

PubMed ID	Title	Journal	Year
23836911	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells Cho, Y, Hazen, BC, Russell, AP, Kralli, A	J. Biol. Chem.	2013
26481306	Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle Cho, Y, Hazen, BC, Gandra, PG, Ward, SR, Schenk, S, Russell, AP, Kralli, A	FASEB J.	2016

Participants

Input

Perm1 gene [nucleoplasm] (Mus musculus)

Output

Perm1 [nucleoplasm] (Mus musculus)

This event is regulated

Positively by

Regulator

Esrra [nucleoplasm] (Mus musculus)

Orthologous Events

Expression of PERM1 (Homo sapiens)

Authored

May, B (2016-09-25)

Reviewed

Kralli, A (2016-11-20)

Created

May, B (2016-09-26)

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