Reactome | RUNX1 regulates transcription of genes involved in BCR signaling

RUNX1 regulates transcription of genes involved in BCR signaling

Stable Identifier

R-HSA-8939245

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RUNX1 regulates transcription of genes involved in BCR signaling

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The RUNX1:CBFB complex, in association with transcription co-factors ELF1 (MEF), ELF2 (NERF2) or PAX5 (BSAP) stimulates transcription of the BLK gene, encoding a B-cell specific tyrosine kinase involved in B cell receptor (BCR) signaling, B cell development and differentiation (Libermann et al. 1999, Cho et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
10455134	AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter Libermann, TA, Pan, Z, Akbarali, Y, Hetherington, CJ, Boltax, J, Yergeau, DA, Zhang, DE	J. Biol. Chem.	1999
14970218	Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene Cho, JY, Akbarali, Y, Zerbini, LF, Gu, X, Boltax, J, Wang, Y, Oettgen, P, Zhang, DE, Libermann, TA	J. Biol. Chem.	2004