BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5

Stable Identifier
Reaction [omitted]
Homo sapiens
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Binding of RUNX1 in complex with ELF1, ELF2 or PAX5 (BSAP) to the BLK gene promoter stimulates BLK transcription. The BLK gene encodes B-cell specific tyrosine kinase BLK (B lymphocyte kinase) involved in B cell receptor (BCR) signaling and B cell development and differentiation (Libermann et al. 1999, Cho et al. 2004).

Literature References
PubMed ID Title Journal Year
10455134 AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

Pan, Z, Yergeau, DA, Hetherington, CJ, Akbarali, Y, Libermann, TA, Zhang, DE, Boltax, J

J. Biol. Chem. 1999
14970218 Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene

Wang, Y, Akbarali, Y, Gu, X, Oettgen, P, Cho, JY, Zhang, DE, Zerbini, LF, Libermann, TA, Boltax, J

J. Biol. Chem. 2004
This event is regulated