RUNX1 binds ELF2

Stable Identifier
R-HSA-8938930
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 binds ELF2
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The RUNX1:CBFB complex binds to ELF2 (NERF), a member of the ETS family of transcription factors. The interaction involves a basic amino acid region upstream of the ETS domain of ELF2 and the runt domain of RUNX1 (Cho et al. 2004).
Literature References
PubMed ID Title Journal Year
14970218 Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene

Cho, JY, Akbarali, Y, Zerbini, LF, Gu, X, Boltax, J, Wang, Y, Oettgen, P, Zhang, DE, Libermann, TA

J. Biol. Chem. 2004
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Orthologous Events
RUNX1 binds ELF2 (Bos taurus)
RUNX1 binds ELF2 (Caenorhabditis elegans)
RUNX1 binds ELF2 (Canis familiaris)
RUNX1 binds ELF2 (Danio rerio)
RUNX1 binds ELF2 (Drosophila melanogaster)
RUNX1 binds ELF2 (Gallus gallus)
RUNX1 binds ELF2 (Mus musculus)
RUNX1 binds ELF2 (Rattus norvegicus)
RUNX1 binds ELF2 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-14)
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