Reactome | MARC1,MARC2 reduce N-hydroxylated compounds

MARC1,MARC2 reduce N-hydroxylated compounds

Stable Identifier

R-HSA-8936442

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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MARC1,MARC2 reduce N-hydroxylated compounds

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Mitochondrial amidoxime-reducing components 1 and 2 (MARC1 and 2) are Mo-molybdopterin (Mo-MPT) cofactor-dependent, outer mitochondrial membrane-associated enzymes capable of reducing N-hydroxylated prodrugs and N-hydroxy-L-arginine (NOHA) and N-hydroxy-N-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. They are components of an N-hydroxylated prodrug-converting complex, also containing cytochrome b5 (CYB5B) and NADH cytochrome b5 reductase 3 (CYB5R3) (Jakobs et al. 2014, Gruenewald et al. 2008, Ott et al. 2014, 2015). The reduction of NOHA is described in this reaction.

Literature References

PubMed ID	Title	Journal	Year
25425164	The mammalian molybdenum enzymes of mARC Ott, G, Havemeyer, A, Clement, B	J. Biol. Inorg. Chem.	2015
25144769	The N-reductive system composed of mitochondrial amidoxime reducing component (mARC), cytochrome b5 (CYB5B) and cytochrome b5 reductase (CYB5R) is regulated by fasting and high fat diet in mice Jakobs, HH, Mikula, M, Havemeyer, A, Strzalkowska, A, Borowa-Chmielak, M, Dzwonek, A, Gajewska, M, Hennig, EE, Ostrowski, J, Clement, B	PLoS ONE	2014
19053771	The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs Gruenewald, S, Wahl, B, Bittner, F, Hungeling, H, Kanzow, S, Kotthaus, J, Schwering, U, Mendel, RR, Clement, B	J. Med. Chem.	2008
24423752	Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians Ott, G, Reichmann, D, Boerger, C, Cascorbi, I, Bittner, F, Mendel, RR, Kunze, T, Clement, B, Havemeyer, A	Drug Metab. Dispos.	2014