The complex of VCP/p97 with cofactors UFD1, NPLOC4 and UBXN7 extract ubiquitinated NFE2L2 from the KEAP1-CUL3 ubiquitin ligase complex prior to its 26S proteasome-mediated degradation (Tao et al, 2017; Di Gregorio et al, 2021; reviewed in van den Boom and Meyer, 2020).
van den Boom, J, Meyer, H
Di Gregorio, J, Zervos, AS, Liao, R, Andl, T, Ambivero, CT, Cilenti, L
Rojo de la Vega, M, Chen, H, Zhang, DD, Luo, G, Tao, S, Chapman, E, Wu, T, Tillotson, J, Liu, P
© 2023 Reactome