Reactome | MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)

MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)

Stable Identifier

R-HSA-8874145

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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ATF6B is anchored in the Golgi membrane and cleaved in the lumenal domain to release a N-terminal fragment into the cytosol (Haze et al. 2001, Guan et al. 2009, Odisho et al. 2015). By inference from the homolog ATF6, the MBTPS1 (S1P) cleaves at a RRHLL motif at amino acid residue 440 (Thuerauf et al. 2007). Glycosylation of 5 sites in the lumenal domain of ATF6B is required for cleavage (Guan et al. 2009). Deletion of the C-terminal domain of ATF6B causes increased production of membrane proteins, possibly due to constitutive transit of the N-terminal domain to the nucleus (Choi et al. 2025).

Literature References

PubMed ID	Title	Journal	Year
19693772	N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha Guan, D, Wang, H, Li, VE, Xu, Y, Yang, M, Shen, Z	J. Cell. Biochem.	2009
11256944	Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Haze, K, Okada, T, Yoshida, H, Yanagi, H, Yura, T, Negishi, M, Mori, K	Biochem. J.	2001
25447309	ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells Odisho, T, Zhang, L, Volchuk, A	Exp. Cell Res.	2015