Reactome | MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)

MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)

Stable Identifier

R-HSA-8874145

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

3/5

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MBTPS1 (S1P) cleaves the lumenal domain of ATF6B as ATF6B is anchored in the Golgi membrane (Haze et al. 2001, Guan et al. 2009). By inference from the homolog ATF6, the cleavage occurs at a RRHLL motif at amino acid residue 440. Glycosylation of 5 sites in the lumenal domain of ATF6B is required for cleavage (Guan et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19693772	N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha Yang, M, Li, VE, Shen, Z, Wang, H, Xu, Y, Guan, D	J. Cell. Biochem.	2009
11256944	Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Mori, K, Yura, T, Negishi, M, Yanagi, H, Okada, T, Yoshida, H, Haze, K	Biochem. J.	2001