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CAPNS2 [plasma membrane]
Stable Identifier
R-HSA-8863453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Calpain small subunit 2, CPNS2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CAST binds Ca2+ bound calpain (Homo sapiens)
Calpain1, Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Calpain1:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain1,Calpain2:Ca2+:CAST [plasma membrane] (Homo sapiens)
Calpain1, Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Calpain1:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain activation (Homo sapiens)
Calpain1, Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Calpain1:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain cleaves p35 to p25 (Homo sapiens)
Calpain1, Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Calpain1:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain1,Calpain2:Ca2+:CAST [plasma membrane] (Homo sapiens)
Calpain1, Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
Calpain1:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
Calpain2:Ca2+ [plasma membrane] (Homo sapiens)
CAPNS [plasma membrane] (Homo sapiens)
CAPNS2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96L46 CAPNS2
Gene Names
CAPNS2
Chain
chain:1-248
Reference Genes
BioGPS Gene:84290 CAPNS2
COSMIC (genes):CAPNS2 CAPNS2
CTD Gene:84290 CAPNS2
dbSNP Gene:84290 CAPNS2
ENSEMBL:ENSG00000256812 CAPNS2
ENSEMBL_homo_sapiens_GENE:ENSG00000256812.2 CAPNS2
HGNC:16371 CAPNS2
KEGG Gene (Homo sapiens):84290 CAPNS2
Monarch:84290 CAPNS2
NCBI Gene:84290 CAPNS2
UCSC:Q96L46 CAPNS2
Reference Transcript
RefSeq:NM_032330.2 CAPNS2
Other Identifiers
11730485_at
16819099
223832_PM_s_at
223832_s_at
3661759
3661760
3661761
46924_at
7995712
84290
GE87010
GO:0003824
GO:0004198
GO:0005509
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0016020
GO:0016787
GO:0046872
GO:0110158
GO:0140096
HMNXSV003015720
ILMN_1699809
PH_hs_0034889
TC16000456.hg
g13529283_3p_s_at
Participates
as a member of
CAPNS [plasma membrane] (Homo sapiens)
Other forms of this molecule
CAPNS2 [cytosol]
Inferred To
capns1a [plasma membrane]
(Danio rerio)
CAPNS2 [plasma membrane]
(Bos taurus)
CAPNS2 [plasma membrane]
(Mus musculus)
CAPNS2 [plasma membrane]
(Sus scrofa)
Homologues of CAPNS2 [plasma membrane]
(Danio rerio)
Homologues of CAPNS2 [plasma membrane]
(Sus scrofa)
CAPNS1 [plasma membrane]
(Canis familiaris)
CAPNS1 [plasma membrane]
(Sus scrofa)
capns1b [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_115706.1
OpenTargets
ENSG00000256812
HPA
ENSG00000256812-CAPNS2
GeneCards
Q96L46
Ensembl
ENSG00000256812
,
ENSP00000400882
,
ENST00000457326
PRO
Q96L46
Pharos - Targets
Q96L46
HMDB Protein
HMDBP07629
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.527
2
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.527
2
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