Reactome | CAPNS2 [cytosol]

CAPNS2 [cytosol]

Stable Identifier

R-HSA-8848629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calpain small subunit 2, CPNS2_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS2 [cytosol] (Homo sapiens)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
      - Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS2 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        Calpain activation (Homo sapiens)
        
        Calpain1,Calpain2 [cytosol] (Homo sapiens)
        
        Calpain1 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS2 [cytosol] (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96L46 CAPNS2

Gene Names

CAPNS2

Chain

chain:1-248

Reference Genes

BioGPS Gene:84290 CAPNS2

COSMIC (genes):CAPNS2 CAPNS2

CTD Gene:84290 CAPNS2

dbSNP Gene:84290 CAPNS2

ENSEMBL:ENSG00000256812 CAPNS2

HGNC:16371 CAPNS2

KEGG:hsa:84290 CAPNS2

Monarch:84290 CAPNS2

NCBI Gene:84290 CAPNS2

UCSC:Q96L46 CAPNS2

Reference Transcript

RefSeq:NM_032330.3 CAPNS2

Other Identifiers

11730485_at

16819099

223832_PM_s_at

223832_s_at

3661759

3661760

3661761

46924_at

7995712

84290

GE87010

GO:0003824

GO:0004198

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0016787

GO:0046872

GO:0110158

GO:0140096

HMNXSV003015720

ILMN_1699809

PH_hs_0034889

TC16000456.hg

g13529283_3p_s_at

Participates

as a member of

CAPNS [cytosol] (Homo sapiens)

Other forms of this molecule

CAPNS2 [plasma membrane]

Inferred To

Homologues of CAPNS2 [cytosol] (Danio rerio)

Homologues of CAPNS2 [cytosol] (Sus scrofa)

capns1a [cytosol] (Danio rerio)

capns2 [cytosol] (Xenopus tropicalis)

capns1b [cytosol] (Danio rerio)

CAPNS1 [cytosol] (Bos taurus)

CAPNS1 [cytosol] (Canis familiaris)

CAPNS1 [cytosol] (Sus scrofa)

Capns2 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_115706.1

ENSEMBL

ENSG00000256812, ENST00000457326, ENSP00000400882

OpenTargets

ENSG00000256812

GeneCards

CAPNS2

HPA

ENSG00000256812-CAPNS2

PRO

Q96L46

Pharos - Targets

Q96L46

HMDB Protein

HMDBP07629

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20810 CAST	1	CAST [cytosol] (R-HSA-8848644)	0.527	3
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2