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WDTC1 [nucleoplasm]
Stable Identifier
R-HSA-8863249
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WD and tetratricopeptide repeats protein 1, WDTC1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
WDTC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N5D0 WDTC1
Gene Names
WDTC1, KIAA1037
Chain
chain:1-677
Reference Genes
BioGPS Gene:23038 WDTC1
COSMIC (genes):WDTC1 WDTC1
CTD Gene:23038 WDTC1
dbSNP Gene:23038 WDTC1
ENSEMBL:ENSG00000142784 WDTC1
HGNC:29175 WDTC1
Monarch:23038 WDTC1
NCBI Gene:23038 WDTC1
OMIM:619763 WDTC1
UCSC:Q8N5D0 WDTC1
Reference Transcript
RefSeq:NM_015023.4 WDTC1
RefSeq:NM_001276252.1 WDTC1
RefSeq:XM_011541057.1 WDTC1
Other Identifiers
11718687_a_at
16661351
215497_PM_s_at
215497_s_at
216036_3p_x_at
216036_PM_x_at
216036_x_at
23038
2326913
2326914
2326916
2326917
2326918
2326919
2326920
2326921
2326922
2326923
2326924
2326925
2326926
2326927
2326928
2326932
2326934
2326935
2326936
2326937
2326938
2326939
2326940
2326941
2326942
2326943
2326944
2326945
2326946
40829_PM_at
40829_at
7899289
A_14_P127580
A_14_P130103
A_23_P86054
A_24_P102895
GE53708
GO:0000122
GO:0001701
GO:0004857
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005975
GO:0006006
GO:0006355
GO:0008361
GO:0016567
GO:0032869
GO:0035264
GO:0042393
GO:0042826
GO:0043226
GO:0045717
GO:0048856
GO:0055082
GO:0080008
GO:0098772
HMNXSV003013980
Hs.172825.1.S1_3p_a_at
Hs.172825.1.S1_3p_s_at
Hs.172825.2.S1_3p_a_at
Hs.172825.2.S1_3p_s_at
ILMN_1707600
PH_hs_0010348
TC01000358.hg
Participates
as a member of
DCAF protein [nucleoplasm] (Homo sapiens)
Inferred To
Wdtc1 [nucleoplasm]
(Mus musculus)
Wdtc1 [nucleoplasm]
(Rattus norvegicus)
adp [nucleoplasm]
(Drosophila melanogaster)
adpr-1 [nucleoplasm]
(Caenorhabditis elegans)
WDTC1 [nucleoplasm]
(Bos taurus)
WDTC1 [nucleoplasm]
(Canis familiaris)
WDTC1 [nucleoplasm]
(Gallus gallus)
WDTC1 [nucleoplasm]
(Sus scrofa)
wdtc1 [nucleoplasm]
(Danio rerio)
wdtc1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000319394
,
ENST00000447062
,
ENSP00000434578
,
ENSP00000355317
,
ENSP00000317971
,
ENST00000361771
OpenTargets
ENSG00000142784
HPA
ENSG00000142784-WDTC1
PRO
Q8N5D0
Pharos - Targets
Q8N5D0
PDB
3I7N
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUI1 DECR2
2
DECR2 [cytosol]
(R-HSA-9033149)
DECR2 [peroxisomal membrane]
(R-HSA-6786710)
0.499
2
UniProt:Q96IK1 BOD1
1
BOD1 [nucleoplasm]
(R-HSA-9821926)
0.499
3
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