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PNOC(130-146) [extracellular region]
Stable Identifier
R-HSA-374749
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Nociceptin, PNOC_HUMAN, PNOC
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Nociceptin receptor binds to nociceptin (Homo sapiens)
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
PNOC(130-146) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13519 PNOC
Gene Names
PNOC, OFQ
Chain
signal peptide:1-19, propeptide:20-95, peptide:98-127, peptide:130-146, peptide:149-165, propeptide:169-176
Reference Genes
BioGPS Gene:5368 PNOC
COSMIC (genes):PNOC PNOC
CTD Gene:5368 PNOC
dbSNP Gene:5368 PNOC
ENSEMBL:ENSG00000168081 PNOC
HGNC:9163 PNOC
KEGG:hsa:5368 PNOC
Monarch:5368 PNOC
NCBI Gene:5368 PNOC
OMIM:601459 PNOC
UCSC:Q13519 PNOC
Reference Transcript
RefSeq:NM_001284244.1 PNOC
RefSeq:NM_006228.4 PNOC
Other Identifiers
11725242_at
11754111_s_at
11761725_a_at
17067393
205901_PM_at
205901_at
3091701
3091703
3091704
3091705
3091706
3091707
3091708
3091709
3091712
40730_at
5368
8145603
A_14_P118013
A_23_P253321
GE59194
GO:0001515
GO:0005184
GO:0005576
GO:0005886
GO:0007165
GO:0007218
GO:0007268
GO:0007270
GO:0007565
GO:0007600
GO:0019233
GO:0022414
GO:0023052
GO:0030425
GO:0031628
GO:0043025
GO:0043679
GO:0045202
GO:0048018
GO:0050877
GO:0097060
GO:0098772
HMNXSV003046267
ILMN_1676003
PH_hs_0024193
TC08000217.hg
U48263_at
g11079650_3p_at
Participates
as an input of
Nociceptin receptor binds to nociceptin (Homo sapiens)
as a component of
Nociceptin receptor:Nociceptin [plasma membrane] (Homo sapiens)
Inferred To
PNOC [extracellular region]
(Bos taurus)
PNOC [extracellular region]
(Canis familiaris)
PNOC [extracellular region]
(Gallus gallus)
PNOC [extracellular region]
(Sus scrofa)
pnocb [extracellular region]
(Danio rerio)
pnoc [extracellular region]
(Xenopus tropicalis)
Pnoc [extracellular region]
(Mus musculus)
Pnoc [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001271173.1
,
NP_006219.1
ENSEMBL
ENSP00000301908
,
ENST00000301908
,
ENST00000522209
,
ENSP00000430145
OpenTargets
ENSG00000168081
HPA
ENSG00000168081-PNOC
PRO
Q13519
Pharos - Targets
Q13519
HMDB Protein
HMDBP13991
PDB
8F7X
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