Reactome | p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane]

p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane]

Stable Identifier

R-HSA-8852533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Macrophage-stimulating protein receptor, RON_HUMAN, MST1R beta chain

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q04912 MST1R

Gene Names

MST1R, PTK8, RON

Chain

signal peptide:1-24, chain:25-1400, chain:25-304, chain:310-1400

Reference Genes

BioGPS Gene:4486 MST1R

COSMIC (genes):MST1R MST1R

CTD Gene:4486 MST1R

dbSNP Gene:4486 MST1R

ENSEMBL:ENSG00000164078 MST1R

ENSEMBL_homo_sapiens_GENE:ENSG00000164078.14 MST1R

HGNC:7381 MST1R

KEGG Gene (Homo sapiens):4486 MST1R

Monarch:4486 MST1R

NCBI Gene:4486 MST1R

OMIM:600168 MST1R

UCSC:Q04912 MST1R

Reference Transcript

Other Identifiers

11725019_a_at

11749262_a_at

11749743_a_at

11752174_a_at

1317_at

16954295

205455_PM_at

205455_at

2674925

2674926

2674927

2674928

2674929

2674930

2674931

2674932

2674933

2674934

2674938

2674939

2674941

2674943

2674945

2674946

2674947

2674948

2674949

2674950

2674951

2674952

2674953

2674954

2674955

2674956

2674957

2674958

2674959

2674960

4486

8087547

A_23_P256312

GE81156

GO:0000166

GO:0001725

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005011

GO:0005515

GO:0005524

GO:0005773

GO:0005856

GO:0005886

GO:0006468

GO:0006909

GO:0006952

GO:0007165

GO:0007169

GO:0007338

GO:0007399

GO:0008284

GO:0009615

GO:0009986

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0019899

GO:0022414

GO:0023052

GO:0036211

GO:0038145

GO:0043226

GO:0043235

GO:0043406

GO:0045087

GO:0048856

GO:0048870

GO:0050896

GO:0051897

GO:0060089

GO:0098542

GO:0140096

HMNXSV003001375

HMNXSV003021167

ILMN_1688154

PH_hs_0000373

TC03001421.hg

X70040_at

g4505264_3p_at

g4505264_3p_x_at

Participates

as a component of

p-4Y-MST1R dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

MST1R (310-1400) [plasma membrane]

MST1R (25-304) [plasma membrane]

Inferred To

Homologues of p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Bos taurus)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Canis familiaris)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Danio rerio)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Gallus gallus)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Mus musculus)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Rattus norvegicus)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Sus scrofa)

phospho-p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1238

Coordinate

1238

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1239

Coordinate

1239

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1353

Coordinate

1353

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1360

Coordinate

1360

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001231866.1, NP_002438.2

ZINC - World Drugs

RON_HUMAN

Guide to Pharmacology - Targets

1816

OpenTargets

ENSG00000164078

ZINC - FDA approved

RON_HUMAN

ZINC - Substances

RON_HUMAN

ZINC target

Q04912

ZINC - Biogenic

RON_HUMAN

PRO

Q04912

PDB

4QT8, 3PLS, 4FWW

ZINC - Investigational

RON_HUMAN

GeneCards

Q04912

HPA

ENSG00000164078-MST1R

Ensembl

ENSG00000164078, ENST00000621387, ENSP00000482642, ENSP00000341325, ENST00000296474, ENST00000344206, ENSP00000296474

Pharos - Targets

Q04912

ZINC - Predictions - Purchasable

RON_HUMAN

HMDB Protein

HMDBP01157

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26927 MST1	3	MST1(19-483) [extracellular region] (R-HSA-6800207) MST1(484-711) [extracellular region] (R-HSA-6800230) pro-MST1 [extracellular region] (R-HSA-6800227)	0.715	5
UniProt:O43157 PLXNB1	2	PLXNB1 [plasma membrane] (R-HSA-3008951) p-Y-PLXNB1 [plasma membrane] (R-HSA-419609)	0.524	3
UniProt:Q9ULL4 PLXNB3	1	PLXNB3 [plasma membrane] (R-HSA-416675)	0.524	2