Reactome | CCR8 binds CCL1

CCR8 binds CCL1

Stable Identifier

R-HSA-8851352

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        CCR8 binds CCL1 (Homo sapiens)

General

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CCR8 is the receptor for CCL1 (Roos et al. 1997, Tiffany et al. 1997)Goya et al. 1998, Dairaghi et al. 1999). CCL1-induced mobilization of intracellular calcium was inhibited by pertussis toxin, suggesting that CCR8 is coupled to the Gi class of Galpha subunits (Tiffany et al. 1997, Goya et al. 1998)

Literature References

PubMed ID	Title	Journal	Year
9207005	Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 Murphy, PM, Locati, M, Tiffany, HL, Combadiere, C, Gao, JL, Modi, W, Pease, J, Bonner, TI, Lautens, LL	J Exp Med	1997