Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CCL1 [extracellular region]
Stable Identifier
R-HSA-8851331
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C-C motif chemokine 1, CCL1_HUMAN, I-309
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CCR8 binds CCL1 (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22362 CCL1
Gene Names
CCL1, SCYA1
Chain
signal peptide:1-23, chain:24-96
Reference Genes
BioGPS Gene:6346 CCL1
COSMIC (genes):CCL1 CCL1
CTD Gene:6346 CCL1
dbSNP Gene:6346 CCL1
ENSEMBL:ENSG00000108702 CCL1
HGNC:10609 CCL1
KEGG:hsa:6346 CCL1
Monarch:6346 CCL1
NCBI Gene:6346 CCL1
OMIM:182281 CCL1
UCSC:P22362 CCL1
Reference Transcript
RefSeq:NM_002981.2 CCL1
Other Identifiers
11737312_at
16843309
207533_PM_at
207533_at
33965_at
3753221
3753222
3753226
3753227
3753228
6346
8014160
A_23_P49759
GE78967
GO:0002376
GO:0005125
GO:0005576
GO:0005615
GO:0006874
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007204
GO:0008009
GO:0016032
GO:0030335
GO:0032740
GO:0048018
GO:0048020
GO:0048245
GO:0048870
GO:0050729
GO:0061844
GO:0070098
GO:0090026
GO:0098542
GO:0098772
HMNXSV003040232
ILMN_2086965
M57506_rna1_at
PH_hs_0004189
TC17001360.hg
g4506832_3p_at
Participates
as an input of
CCR8 binds CCL1 (Homo sapiens)
as a component of
CCR8:CCL1 [plasma membrane] (Homo sapiens)
Inferred To
CCL1 [extracellular region]
(Bos taurus)
CCL1 [extracellular region]
(Gallus gallus)
CCL1 [extracellular region]
(Sus scrofa)
CCL26 [extracellular region]
(Gallus gallus)
CCLi7 [extracellular region]
(Gallus gallus)
CCLi8 [extracellular region]
(Gallus gallus)
Ccl1 [extracellular region]
(Mus musculus)
Ccl1 [extracellular region]
(Rattus norvegicus)
CCL4 [extracellular region]
(Gallus gallus)
CX3CL1 [extracellular region]
(Gallus gallus)
CCLi9 [extracellular region]
(Gallus gallus)
Homologues of CCL1 [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_002972.1
ENSEMBL
ENST00000225842
,
ENSP00000225842
,
ENSG00000108702
OpenTargets
ENSG00000108702
GeneCards
CCL1
HPA
ENSG00000108702-CCL1
PRO
P22362
Pharos - Targets
P22362
GlyGen
P22362
PDB
1EL0
,
4OIJ
,
4OIK
,
8U1U
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text