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Chemokine receptors bind chemokines
Stable Identifier
R-HSA-380108
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
General
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Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind.
Literature References
PubMed ID
Title
Journal
Year
10807766
Chemokine receptors and their role in inflammation and infectious diseases
Finn, A
,
Murdoch, C
Blood
2000
15578986
Chemokine-chemokine receptor network in immune cell trafficking
Kim, CH
Curr Drug Targets Immune Endocr Metabol Disord
2004
11544102
Chemokine receptors
Horuk, R
Cytokine Growth Factor Rev
2001
Participants
Events
Receptor CCR10 binds CCL27 and 28 ligands
(Homo sapiens)
Receptor CCR6 binds CCL20 ligand
(Homo sapiens)
Receptor CCR7 binds CCL19 and 21 ligands
(Homo sapiens)
Receptor CCR9 binds CCL25 ligand
(Homo sapiens)
CX3CR1 binds CX3CL1
(Homo sapiens)
Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta
(Homo sapiens)
Receptor CXCR1 binds CXCL6 and CXCL8 ligands
(Homo sapiens)
Receptor CXCR2 binds ligands CXCL1 to 7
(Homo sapiens)
Receptor CXCR3 binds ligands CXCL9 to 11
(Homo sapiens)
Receptors CXCR4 and 7 bind CXCL12 ligand
(Homo sapiens)
CXCR5 binds CXCL13
(Homo sapiens)
Receptor CXCR6 binds CXCL16 ligand
(Homo sapiens)
Receptors CCR1, 2 and 8 bind CCL16 ligand
(Homo sapiens)
Receptors CCR3, 4 and 5 bind CCL5 ligand
(Homo sapiens)
Receptor ACKR2 binds most inflammatory CC chemokines
(Homo sapiens)
Receptor CCR11 binds CCL19, CCL21 & CCL25
(Homo sapiens)
CCRL2 binds CCL19
(Homo sapiens)
CCR8 binds CCL1
(Homo sapiens)
CCR2, CCR3 bind CCL13
(Homo sapiens)
Participates
as an event of
Peptide ligand-binding receptors (Homo sapiens)
Orthologous Events
Chemokine receptors bind chemokines (Bos taurus)
Chemokine receptors bind chemokines (Canis familiaris)
Chemokine receptors bind chemokines (Danio rerio)
Chemokine receptors bind chemokines (Gallus gallus)
Chemokine receptors bind chemokines (Mus musculus)
Chemokine receptors bind chemokines (Rattus norvegicus)
Chemokine receptors bind chemokines (Sus scrofa)
Authored
Jassal, B (2008-11-07)
Created
Jassal, B (2008-11-07)
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