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CCR8 [plasma membrane]
Stable Identifier
R-HSA-373237
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-C chemokine receptor type 8, CCR8_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CCR8 binds CCL1 (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR8:CCL1 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51685 CCR8
Gene Names
CCR8, CKRL1, CMKBR8, CMKBRL2
Chain
chain:1-355
Reference Genes
BioGPS Gene:1237 CCR8
COSMIC (genes):CCR8 CCR8
CTD Gene:1237 CCR8
dbSNP Gene:1237 CCR8
ENSEMBL:ENSG00000179934 CCR8
ENSEMBL_homo_sapiens_GENE:ENSG00000179934.7 CCR8
HGNC:1609 CCR8
KEGG Gene (Homo sapiens):1237 CCR8
Monarch:1237 CCR8
NCBI Gene:1237 CCR8
OMIM:601834 CCR8
UCSC:P51685 CCR8
Reference Transcript
RefSeq:NM_005201.3 CCR8
Other Identifiers
11735871_s_at
1237
16939380
208059_PM_at
208059_at
2618176
2618178
2618180
2618182
35088_at
8078888
A_14_P121246
A_23_P69012
GE57233
GO:0002376
GO:0004930
GO:0004950
GO:0005886
GO:0006935
GO:0006955
GO:0007155
GO:0007165
GO:0007186
GO:0007204
GO:0009897
GO:0015026
GO:0016020
GO:0016493
GO:0019722
GO:0019957
GO:0023052
GO:0048870
GO:0060089
GO:0060326
GO:0070098
HMNXSV003055451
TC03000200.hg
U45983_at
g4885120_3p_at
Participates
as an input of
CCR8 binds CCL1 (Homo sapiens)
as a member of
CCR1,2,8 [plasma membrane] (Homo sapiens)
as a component of
CCR8:CCL1 [plasma membrane] (Homo sapiens)
Inferred To
Ccr8 [plasma membrane]
(Mus musculus)
Ccr8 [plasma membrane]
(Rattus norvegicus)
npr-32 [plasma membrane]
(Caenorhabditis elegans)
LOC105946838 [plasma membrane]
(Xenopus tropicalis)
CCR8 [plasma membrane]
(Bos taurus)
CCR8 [plasma membrane]
(Gallus gallus)
CCR8 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005192.1
Guide to Pharmacology - Targets
65
OpenTargets
ENSG00000179934
ZINC - Substances
CCR8_HUMAN
ZINC target
P51685
ZINC - Biogenic
CCR8_HUMAN
PRO
P51685
PDB
8U1U
,
8KFY
,
8KFX
,
8KFZ
,
8TLM
ZINC - Investigational
CCR8_HUMAN
ZINC - Metabolites
CCR8_HUMAN
HPA
ENSG00000179934-CCR8
GeneCards
P51685
Ensembl
ENSG00000179934
,
ENST00000326306
,
ENSP00000326432
Pharos - Targets
P51685
ZINC - Predictions - Purchasable
CCR8_HUMAN
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