RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

Stable Identifier
Reaction [transition]
Homo sapiens
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The RAB3GAP1:RAB3GAP2 complex promotes nucleotide exchange of RAB18 at the ER membrane, activating it (Gerondopoulos et al, 2014). How active RAB18 contributes to COPI-independent retrograde Golgi-to-ER traffic remains to be worked out, however a role in tubule tethering is postulated based on the interaction of RAB18 with components of the ER localized NRZ tethering factor (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014).

Literature References
PubMed ID Title Journal Year
18664496 Rab18 and Rab43 have key roles in ER-Golgi trafficking

Presley, JF, Verbich, D, Lodge, R, Murshid, A, Dejgaard, K, Kizilay, O, Simpson, JC, Pepperkok, R, Ly-Hartig, TB, Dejgaard, SY, Erman, A

J. Cell. Sci. 2008
24891604 Rab18 and a Rab18 GEF complex are required for normal ER structure

Aligianis, I, Handley, MT, Barr, FA, Gerondopoulos, A, Yoshimura, S, Bastos, RN, Anderson, R, Carpanini, S

J. Cell Biol. 2014
25453831 Toward a comprehensive map of the effectors of rab GTPases

Gillingham, AK, Sinka, R, Lilley, KS, Torres, IL, Munro, S

Dev. Cell 2014
Catalyst Activity

guanyl-nucleotide exchange factor activity of RAB3GAP1:RAB3GAP2:RAB18:GDP [endoplasmic reticulum membrane]

Orthologous Events
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