Reactome | RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

Stable Identifier

R-HSA-8850041

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

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The RAB3GAP1:RAB3GAP2 complex promotes nucleotide exchange of RAB18 at the ER membrane, activating it (Gerondopoulos et al, 2014). How active RAB18 contributes to COPI-independent retrograde Golgi-to-ER traffic remains to be worked out, however a role in tubule tethering is postulated based on the interaction of RAB18 with components of the ER localized NRZ tethering factor (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
18664496	Rab18 and Rab43 have key roles in ER-Golgi trafficking Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF	J. Cell. Sci.	2008
24891604	Rab18 and a Rab18 GEF complex are required for normal ER structure Gerondopoulos, A, Bastos, RN, Yoshimura, S, Anderson, R, Carpanini, S, Aligianis, I, Handley, MT, Barr, FA	J. Cell Biol.	2014
25453831	Toward a comprehensive map of the effectors of rab GTPases Gillingham, AK, Sinka, R, Torres, IL, Lilley, KS, Munro, S	Dev. Cell	2014