COPI-independent Golgi-to-ER retrograde traffic

Stable Identifier
Homo sapiens
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In addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo such as glycosylation enzymes and Shiga and Shiga-like toxin through tubular carriers rather than vesicles (White et al, 1999; Girod et al, 1999; reviewed in Heffernan and Simpson, 2014). In the absence of a COPI coat, the membrane curvature necessary to initiate tubulation may be provided through the action of phospholipase A, which hydrolyzes phospholipids at the sn2 position to yield lysophospholipids. This activity is countered by lysophospholipid acyltransferases, and the balance of these may influence whether transport tubules or transport vesicles form (de Figuiredo et al, 1998; reviewed in Bechler et al, 2012). RAB6-dependent tubules also depend on the dynein-dynactin motor complex and the hoomodimeric Bicaudal proteins (Matanis et al, 2002; Yamada et al, 2013; reviewed in Heffernan and Simpson, 2014).

Literature References
PubMed ID Title Journal Year
22130221 A PLA1-2 punch regulates the Golgi complex

Bechler, ME, Brown, WJ, de Figueiredo, P

Trends Cell Biol. 2012
10562278 Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells

Girod, A, White, J, Grill, S, Reinsch, S, Johannes, L, Stelzer, EH, Keller, P, Tzschaschel, B, Goud, B, Echard, A, Mallard, F

J. Cell Biol. 1999
12447383 Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex

Weide, T, Grosveld, F, Matanis, T, Wulf, P, Barnekow, A, Galjart, N, Akhmanova, A, Stepanova, T, De Zeeuw, CI, Goud, B, Hoogenraad, CC, del Nery, E

Nat. Cell Biol. 2002
9671731 Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation

Drecktrah, D, Katzenellenbogen, JA, Strang, M, Brown, WJ, de Figueiredo, P

Proc. Natl. Acad. Sci. U.S.A. 1998
23783758 Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement

Fukui, M, Mikuni, S, Jin, M, Kumamoto, K, Arai, Y, Tsukasaki, Y, Kinjo, M, Nagai, T, Watanabe, TM, Yamada, M, Hirotsune, S, Toba, S

Nat Commun 2013
25233431 The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport

Simpson, JC, Heffernan, LF

Biochem. Soc. Trans. 2014
10559986 Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

Girod, A, Lord, JM, Johannes, L, Simpson, JC, Pepperkok, R, Goud, B, Storrie, B, Nilsson, T, Roberts, LM

Nat. Cell Biol. 1999
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