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HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
Stable Identifier
R-HSA-882032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HLA-DRB4, DRB4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
LAG3 (CD233) binds MHC II (Homo sapiens)
LAG3:MHC II [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Recruitment of clathrin coated vesicle by Ii (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13762 HLA-DRB4
Gene Names
HLA-DRB4
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3126 HLA-DRB4
CTD Gene:3126 HLA-DRB4
dbSNP Gene:3126 HLA-DRB4
ENSEMBL:ENSG00000227357 HLA-DRB4
HGNC:4952 HLA-DRB4
KEGG:hsa:3126 HLA-DRB4
Monarch:3126 HLA-DRB4
NCBI Gene:3126 HLA-DRB4
UCSC:P13762 HLA-DRB4
Reference Transcript
RefSeq:XM_017030290.1 HLA-DRB4
RefSeq:NM_021983.4 HLA-DRB4
Other Identifiers
11755998_x_at
17037192
209728_3p_at
209728_PM_at
209728_at
2950023
2950025
2950057
2950060
3126
32035_at
4048248
4048272
4048275
41723_s_at
A_24_P370472
GO:0000139
GO:0002250
GO:0002376
GO:0002503
GO:0002504
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031902
GO:0032588
GO:0042605
GO:0042613
GO:0043226
GO:0050778
GO:0050870
GO:0065003
GO:0098553
HMNXSV003043789
Hs.279930.1.S1_3p_x_at
ILMN_1679617
ILMN_1752592
ILMN_2159694
TC6_mann_hap4000159.hg
TC6_mann_hap4000161.hg
TC6_mcf_hap5000169.hg
TC6_ssto_hap7000163.hg
g13529055_3p_s_at
g13529055_3p_x_at
Participates
as a member of
HLA II beta chain [plasma membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DR beta 4 chain [lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [Golgi membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
Inferred To
RT1-Db1 [plasma membrane]
(Rattus norvegicus)
b2m [plasma membrane]
(Danio rerio)
H2-Eb1 [plasma membrane]
(Mus musculus)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Bos taurus)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Gallus gallus)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Sus scrofa)
BLB1 [plasma membrane]
(Gallus gallus)
mhc2-dab [plasma membrane]
(Xenopus tropicalis)
LOC100153139 [plasma membrane]
(Sus scrofa)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Bos taurus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Gallus gallus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Mus musculus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Sus scrofa)
BLB2 [plasma membrane]
(Gallus gallus)
zmp:0000001138 [plasma membrane]
(Danio rerio)
RT1-Db2 [plasma membrane]
(Rattus norvegicus)
SLA-DRB1 [plasma membrane]
(Sus scrofa)
H2-Eb2 [plasma membrane]
(Mus musculus)
Cross References
RefSeq
NP_068818.4
,
XP_016885779.1
ENSEMBL
ENST00000411565
,
ENSP00000412031
,
ENSP00000410857
,
ENST00000457451
PRO
P13762
GlyGen
P13762
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