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HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
Stable Identifier
R-HSA-2130418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
HLA-DRB4, DRB4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Cleavage of lip22 to lip10 (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Disassociation of CLIP from MHC II (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Generation of CLIP from lip10 (Homo sapiens)
MHC II:CLIP [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
MHC II:lip10 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)
MHC II:lip22 nonamer [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Loading of antigenic peptides (Homo sapiens)
peptide free MHC II:HLA-DM [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)
Nonameric complex [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [lysosomal membrane] (Homo sapiens)
MHC II alpha/beta dimer [lysosomal membrane] (Homo sapiens)
HLA II beta chain [lysosomal membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13762 HLA-DRB4
Gene Names
HLA-DRB4
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3126 HLA-DRB4
CTD Gene:3126 HLA-DRB4
dbSNP Gene:3126 HLA-DRB4
ENSEMBL:ENSG00000227357 HLA-DRB4
HGNC:4952 HLA-DRB4
KEGG:hsa:3126 HLA-DRB4
Monarch:3126 HLA-DRB4
NCBI Gene:3126 HLA-DRB4
UCSC:P13762 HLA-DRB4
Reference Transcript
RefSeq:XM_017030290.1 HLA-DRB4
RefSeq:NM_021983.4 HLA-DRB4
Other Identifiers
11755998_x_at
17037192
209728_3p_at
209728_PM_at
209728_at
2950023
2950025
2950057
2950060
3126
32035_at
4048248
4048272
4048275
41723_s_at
A_24_P370472
GO:0000139
GO:0002250
GO:0002376
GO:0002503
GO:0002504
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031902
GO:0032588
GO:0042605
GO:0042613
GO:0043226
GO:0050778
GO:0050870
GO:0065003
GO:0098553
HMNXSV003043789
Hs.279930.1.S1_3p_x_at
ILMN_1679617
ILMN_1752592
ILMN_2159694
TC6_mann_hap4000159.hg
TC6_mann_hap4000161.hg
TC6_mcf_hap5000169.hg
TC6_ssto_hap7000163.hg
g13529055_3p_s_at
g13529055_3p_x_at
Participates
as a member of
HLA II beta chain [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DR beta 4 chain [lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [Golgi membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [transport vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
Inferred To
H2-Eb1 [lysosomal membrane]
(Mus musculus)
b2m [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Bos taurus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Mus musculus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Sus scrofa)
RT1-Db1 [lysosomal membrane]
(Rattus norvegicus)
mhc2-dab [lysosomal membrane]
(Xenopus tropicalis)
H2-Eb2 [lysosomal membrane]
(Mus musculus)
LOC100153139 [lysosomal membrane]
(Sus scrofa)
RT1-Db2 [lysosomal membrane]
(Rattus norvegicus)
SLA-DRB1 [lysosomal membrane]
(Sus scrofa)
zmp:0000001138 [lysosomal membrane]
(Danio rerio)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Bos taurus)
HLA class II histocompatibility antigen, DR beta 4 chain [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_068818.4
,
XP_016885779.1
ENSEMBL
ENST00000411565
,
ENSP00000412031
,
ENSP00000410857
,
ENST00000457451
PRO
P13762
GlyGen
P13762
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