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What is Reactome ?
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RT1-Db1 [plasma membrane]
Stable Identifier
R-RNO-882032-2
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
HLA class II histocompatibility antigen, DR beta 4 chain, P18211
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
MHC class II antigen presentation (Rattus norvegicus)
Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
LAG3 (CD233) binds MHC II (Rattus norvegicus)
LAG3:MHC II [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Recruitment of clathrin coated vesicle by Ii (Rattus norvegicus)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)
peptide loaded MHC class II [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-inhibition by PD-1 (Rattus norvegicus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Change of PKC theta conformation (Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Generation of second messenger molecules (Rattus norvegicus)
Phosphorylation of PLC-gamma1 (Rattus norvegicus)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Rattus norvegicus)
Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of SLP-76 (Rattus norvegicus)
Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of TBSMs in LAT (Rattus norvegicus)
Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
Activation of Lck (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Inactivation of LCK by PTPN22 (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Inactivation of Lck by Csk (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
Activation of ZAP-70 (Rattus norvegicus)
Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
MHC class II alpha/beta dimer [plasma membrane] (Rattus norvegicus)
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
RT1-Db1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P18211
Gene Names
RT1-Db1
Reference Genes
ENSEMBL:ENSRNOG00000033215
UCSC:P18211 RT1-Db1
Participates
as a member of
HLA II beta chain [plasma membrane] (Rattus norvegicus)
Homologues of HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
RT1-Db1 [lumenal side of endoplasmic reticulum membrane]
RT1-Db1 [ER to Golgi transport vesicle membrane]
RT1-Db1 [Golgi membrane]
RT1-Db1 [trans-Golgi network membrane]
RT1-Db1 [transport vesicle membrane]
RT1-Db1 [clathrin-coated endocytic vesicle membrane]
RT1-Db1 [endocytic vesicle membrane]
RT1-Db1 [lysosomal membrane]
Inferred From
HLA class II histocompatibility antigen, DRB1-15 beta chain [plasma membrane]
(Homo sapiens)
HLA class II histocompatibility antigen, DR beta 4 chain [plasma membrane]
(Homo sapiens)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(Homo sapiens)
HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane]
(Homo sapiens)
Cross References
PRO
P18211
GlyGen
P18211
RGD
1593282
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