Platelet Aggregation (Plug Formation)

Stable Identifier
R-HSA-76009
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Platelet Aggregation (Plug Formation)
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The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds.
Literature References
PubMed ID Title Journal Year
17585075 Adhesion mechanisms in platelet function

Ruggeri, ZM, Mendolicchio, GL

Circ Res 2007
18174460 Cell adhesion mechanisms in platelets

Varga-Szabo, D, Pleines, I, Nieswandt, B

Arterioscler Thromb Vasc Biol 2008
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Orthologous Events
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Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Saccharomyces cerevisiae)
Platelet Aggregation (Plug Formation) (Sus scrofa)
Platelet Aggregation (Plug Formation) (Xenopus tropicalis)
Cross References
BioModels Database
Authored
de Bono, B  (2004-08-13)
Created
Farndale, R  (2004-09-25)
Pace, NP  (2004-09-25)
de Bono, B  (2004-09-25)
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