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Thrombopoietin binds the thrombopoietin receptor
Stable Identifier
R-HSA-443926
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
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Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis. Binding of TPO to its receptor TPOR (c-Mpl) mediates pleiotropic effects on megakaryocyte development leading to significant increase in circulating platelet numbers. TPOR knockout mice show a marked reduction in bone marrow megakaryocytes and blood platelets. Although thrombopoietin (TPO) by itself has little or no effect on platelet aggregation, pretreatment of platelets with TPO augments the aggregation induced by various agonists such as ADP, thrombin, collagen, and adrenaline.
Participants
Input
MPL [plasma membrane]
(Homo sapiens)
THPO [extracellular region]
(Homo sapiens)
Output
TPO:Thrombopoietin receptor [plasma membrane]
(Homo sapiens)
Participates
as an event of
Platelet Aggregation (Plug Formation) (Homo sapiens)
Inferred From
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
Authored
Akkerman, JW (2009-09-04)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-10-19)
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