Thrombin binding to GP1b:IX:V

Stable Identifier
R-HSA-429529
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Thrombin binds to the GP1b-IX-V receptor during platelet aggregation. This leads to increased PAR activation, possibly due to favourable orientation of thrombin towards the PAR extracellular domain.

Literature References
PubMed ID Title Journal Year
12855811 Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

Dumas, JJ, Kumar, R, Seehra, J, Somers, WS, Mosyak, L

Science 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created