Thrombin binding to GP1b:IX:V

Stable Identifier
R-HSA-429529
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Thrombin binding to GP1b:IX:V
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Thrombin binds to the GP1b-IX-V receptor during platelet aggregation. This leads to increased PAR activation, possibly due to favourable orientation of thrombin towards the PAR extracellular domain.

Literature References
PubMed ID Title Journal Year
12855811 Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

Dumas, JJ, Kumar, R, Seehra, J, Somers, WS, Mosyak, L

Science 2003
Participants
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Orthologous Events
Thrombin binding to GP1b:IX:V (Danio rerio)
Thrombin binding to GP1b:IX:V (Mus musculus)
Thrombin binding to GP1b:IX:V (Rattus norvegicus)
Thrombin binding to GP1b:IX:V (Sus scrofa)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2009-07-16)