Reactome | Adrenaline signalling through Alpha-2 adrenergic receptor

Adrenaline signalling through Alpha-2 adrenergic receptor

Stable Identifier

R-HSA-392023

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Adrenaline signalling through Alpha-2 adrenergic receptor

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Adrenaline (epinephrine) signalling via the alpha-2 adrenergic receptor has many effects including inhibition of insulin release in pancreas, induction of glucagon release from pancreas, contraction of sphincters of the gastrointestinal tract, negative feedback processes in neuronal synapses and stimulation of platelet aggregation. This receptor preferentially couples to members of the Gi class of heterotrimeric G-proteins, leading to inhibition af adenylate cyclase and thereby decreased cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
2823383	Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Regan, JW, Caron, MG, Lefkowitz, RJ, Matsui, H, Yang-Feng, TL, Kobilka, TS, Kobilka, BK, Francke, U	Science	1987