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SOS-mediated signalling
Stable Identifier
R-HSA-112412
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
SOS is recruited to the plasma membrane and mediates activation of Ras.
Participants
Events
GRB2-1:SOS1 binds p-IRS1,p-IRS2
(Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
(Homo sapiens)
Participates
as an event of
IRS-mediated signalling (Homo sapiens)
Orthologous Events
SOS-mediated signalling (Bos taurus)
SOS-mediated signalling (Canis familiaris)
SOS-mediated signalling (Drosophila melanogaster)
SOS-mediated signalling (Gallus gallus)
SOS-mediated signalling (Mus musculus)
SOS-mediated signalling (Rattus norvegicus)
SOS-mediated signalling (Sus scrofa)
SOS-mediated signalling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000651
,
BIOMD0000000656
,
BIOMD0000000653
,
BIOMD0000000466
,
BIOMD0000000883
,
BIOMD0000000424
,
BIOMD0000000019
,
BIOMD0000000654
,
BIOMD0000000175
,
BIOMD0000000468
,
BIOMD0000000255
,
BIOMD0000000399
,
BIOMD0000000648
,
BIOMD0000000652
,
BIOMD0000000655
Authored
Charalambous, M (2004-04-29)
Created
Charalambous, M (2004-04-29)
© 2025
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