Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
Stable Identifier
R-HSA-109800
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
SOS-mediated signalling (Homo sapiens)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Homo sapiens)
Participants
components
GRB2-1:SOS1 [cytosol]
(Homo sapiens)
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
Participates
as an input of
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
as an output of
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Homo sapiens)
as a member of
RAS GEFs [plasma membrane] (Homo sapiens)
Inferred To
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Bos taurus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Drosophila melanogaster)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Gallus gallus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Rattus norvegicus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Sus scrofa)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Xenopus tropicalis)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text