Reactome | Transport of nucleotide sugars

Transport of nucleotide sugars

Stable Identifier

R-HSA-727802

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004).

Literature References

PubMed ID	Title	Journal	Year
12759756	Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) Ishida, N, Kawakita, M	Pflugers Arch	2004
19164095	Analysis and update of the human solute carrier (SLC) gene superfamily Nebert, DW, He, L, Vasiliou, K	Hum Genomics	2009
16981043	Nucleotide-sugar transporters: structure, function and roles in vivo Orellana, A, Rodriguez-Furlán, C, Handford, M	Braz J Med Biol Res	2006