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EIF2B1 [cytosol]
Stable Identifier
R-HSA-72517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2B-alpha, translation initiation factor 2B alpha subunit, eIF-2B GDP-GTP exchange factor, alpha subunit, Translation initiation factor eIF-2B alpha subunit, eIF-2B GDP-GTP exchange factor
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B1 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B1 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B1 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14232 EIF2B1
Gene Names
EIF2B1, EIF2BA
Chain
chain:1-305
Reference Genes
BioGPS Gene:1967 EIF2B1
COSMIC (genes):EIF2B1 EIF2B1
CTD Gene:1967 EIF2B1
dbSNP Gene:1967 EIF2B1
ENSEMBL:ENSG00000111361 EIF2B1
HGNC:3257 EIF2B1
KEGG:hsa:1967 EIF2B1
Monarch:1967 EIF2B1
NCBI Gene:1967 EIF2B1
OMIM:606686 EIF2B1
UCSC:Q14232 EIF2B1
Reference Transcript
RefSeq:NM_001414.3 EIF2B1
Other Identifiers
11717942_at
11717943_s_at
11746147_a_at
16772023
1967
201632_PM_at
201632_at
3476266
3476267
3476268
3476269
3476270
3476273
3476274
3476278
3476280
3476281
3476282
3476283
3476284
3476285
3476286
3476287
3476288
3476289
3476290
37665_at
44888_at
7967473
A_23_P105313
GE60177
GO:0002183
GO:0002376
GO:0003743
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005851
GO:0005886
GO:0006412
GO:0006413
GO:0009408
GO:0009749
GO:0014003
GO:0016020
GO:0042802
GO:0043434
GO:0044237
GO:0045182
GO:0048856
GO:0050852
GO:0098772
HMNXSV003043349
ILMN_1753716
PH_hs_0004533
TC12002092.hg
X95648_at
g4503502_3p_at
Participates
as a component of
eIF2B subunits complex [cytosol] (Homo sapiens)
Inferred To
Eif2b1 [cytosol]
(Mus musculus)
Eif2b1 [cytosol]
(Rattus norvegicus)
gcn3 [cytosol]
(Schizosaccharomyces pombe)
GCN3 [cytosol]
(Saccharomyces cerevisiae)
EIF2B1 [cytosol]
(Bos taurus)
EIF2B1 [cytosol]
(Caenorhabditis elegans)
EIF2B1 [cytosol]
(Canis familiaris)
EIF2B1 [cytosol]
(Gallus gallus)
EIF2B1 [cytosol]
(Plasmodium falciparum)
EIF2B1 [cytosol]
(Sus scrofa)
eIF2Balpha [cytosol]
(Drosophila melanogaster)
Ghost homologue of EIF2B1 [cytosol]
(Xenopus tropicalis)
eif2b1 [cytosol]
(Danio rerio)
eif2b1 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001405.1
OpenTargets
ENSG00000111361
ENSEMBL
ENSP00000444183
,
ENST00000537073
,
ENSP00000416250
,
ENST00000424014
HPA
ENSG00000111361-EIF2B1
PRO
Q14232
Pharos - Targets
Q14232
Orphanet
EIF2B1
GlyGen
Q14232
PDB
7KMF
,
7VLK
,
6K71
,
7D44
,
6O85
,
7TRJ
,
7RLO
,
7F64
,
3ECS
,
6EZO
,
7D45
,
6O81
,
6O9Z
,
8TQZ
,
6CAJ
,
7F66
,
7L70
,
7D46
,
7D43
,
7L7G
,
7KMA
,
7F67
,
6K72
HMDB Protein
HMDBP08374
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2D1 ATF5
3
ATF5 [mitochondrial matrix]
(R-HSA-9841250)
ATF5 [cytosol]
(R-HSA-9841253)
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.556
5
UniProt:P43115 PTGER3
1
PTGER3 [plasma membrane]
(R-HSA-391828)
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
4
UniProt:P07550 ADRB2
5
ADRB2 [plasma membrane]
(R-HSA-390647)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
ADRB2 [endosome membrane]
(R-HSA-6783036)
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
0.463
2
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