Reactome | CLP1 [nucleoplasm]

CLP1 [nucleoplasm]

Stable Identifier

R-HSA-72017

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CF II - Clp1, Clp1, Pre-mRNA cleavage complex II protein Clp1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CF II [nucleoplasm] (Homo sapiens)
        
        CLP1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CF II [nucleoplasm] (Homo sapiens)
        
        CLP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92989 CLP1

Gene Names

CLP1, HEAB

Chain

chain:1-425

Reference Genes

BioGPS Gene:10978 CLP1

COSMIC - genes:CLP1 COLEC12

CTD Gene:10978 CLP1

dbSNP Gene:10978 CLP1

ENSEMBL:ENSG00000172409 CLP1

HGNC:16999 CLP1

KEGG:hsa:10978 CLP1

Monarch:10978 CLP1

NCBI Gene:10978 CLP1

OMIM:608757 CLP1

UCSC:Q92989 CLP1

Reference Transcript

Other Identifiers

10978

11735630_a_at

204370_PM_at

204370_at

33149_at

3331401

3331402

3331403

3331404

3331405

3331406

3331407

3331408

3331409

3331410

3331411

3331412

3331424

7940046

A_14_P124396

A_23_P87141

A_24_P252973

GE59387

GO:0000166

GO:0000214

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0005849

GO:0006388

GO:0006396

GO:0006397

GO:0006399

GO:0008033

GO:0016071

GO:0016301

GO:0016740

GO:0021695

GO:0031124

GO:0046404

GO:0048856

GO:0051731

GO:0051734

GO:0051736

GO:0065003

GO:0070922

GO:0098795

HMNXSV003054855

ILMN_1659976

PH_hs_0004915

TC11000470.hg

U73524_at

g5803028_3p_at

Participates

as a component of

as an input of

Formation of the CF II complex (Homo sapiens)

Inferred To

CLP1 [nucleoplasm] (Bos taurus)

CLP1 [nucleoplasm] (Caenorhabditis elegans)

CLP1 [nucleoplasm] (Canis familiaris)

CLP1 [nucleoplasm] (Danio rerio)

CLP1 [nucleoplasm] (Dictyostelium discoideum)

CLP1 [nucleoplasm] (Drosophila melanogaster)

CLP1 [nucleoplasm] (Gallus gallus)

CLP1 [nucleoplasm] (Mus musculus)

CLP1 [nucleoplasm] (Plasmodium falciparum)

CLP1 [nucleoplasm] (Rattus norvegicus)

CLP1 [nucleoplasm] (Saccharomyces cerevisiae)

CLP1 [nucleoplasm] (Schizosaccharomyces pombe)

CLP1 [nucleoplasm] (Sus scrofa)

CLP1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001136069.1, NP_006822.1

OpenTargets

ENSG00000172409

ENSEMBL

ENST00000302731, ENST00000681650, ENSP00000436066, ENSP00000506714, ENSG00000172409, ENST00000525602, ENSP00000304704, ENSP00000434995, ENST00000533682

IntEnz

2.7.1.78

HPA

ENSG00000172409-CLP1

GeneCards

CLP1

PRO

Q92989

Pharos - Targets

Q92989

Orphanet

CLP1

PDB

8HMZ, 8HMY

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z6J9 TSEN54	1	TSEN54 [nucleoplasm] (R-HSA-5696764)	0.666	7
UniProt:O94913 PCF11	1	PCF11 [nucleoplasm] (R-HSA-72019)	0.59	3
UniProt:O43320 FGF16	1	FGF16 [extracellular region] (R-HSA-189918)	0.556	3
UniProt:Q9UPV0 CEP164	1	CEP164 [cytosol] (R-HSA-380305)	0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q14696 MESD			0.556	3
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.556	3
UniProt:P22061-2 PCMT1			0.556	3
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9C0B1-2 Q9C0B12			0.556	3
UniProt:Q8NCG7 DAGLB	1	DAGLB [plasma membrane] (R-HSA-426020)	0.556	3
UniProt:P13994 YJU2B			0.556	3
UniProt:Q8WW01 TSEN15	1	TSEN15 [nucleoplasm] (R-HSA-5696772)	0.527	3
UniProt:Q8NCE0 TSEN2	1	TSEN2 [nucleoplasm] (R-HSA-5696787)	0.527	4

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