Reactome | DAGLB [plasma membrane]

DAGLB [plasma membrane]

Stable Identifier

R-HSA-426020

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Diacylglycerol lipase beta, Sn1-specific diacylglycerol lipase beta, DGLB_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Effects of PIP2 hydrolysis (Homo sapiens)
        
        Arachidonate production from DAG (Homo sapiens)
        
        DAG is metabolized by DAGL to 2-AG (Homo sapiens)
        
        Diacylglycerol lipase [plasma membrane] (Homo sapiens)
        
        DAGLB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NCG7 DAGLB

Gene Names

DAGLB

Chain

chain:1-672

Reference Genes

BioGPS Gene:221955 DAGLB

COSMIC - genes:DAGLB DAGLB

CTD Gene:221955 DAGLB

dbSNP Gene:221955 DAGLB

ENSEMBL:ENSG00000164535 DAGLB

HGNC:28923 DAGLB

KEGG:hsa:221955 DAGLB

Monarch:221955 DAGLB

NCBI Gene:221955 DAGLB

OMIM:614016 DAGLB

UCSC:Q8NCG7 DAGLB

Reference Transcript

Other Identifiers

11720933_s_at

11720934_a_at

11741500_a_at

11762794_at

17055013

221955

225828_PM_at

225828_at

225832_3p_s_at

225832_PM_s_at

225832_s_at

225833_PM_at

225833_at

226640_PM_at

226640_at

3037336

3037338

3037339

3037340

3037341

3037343

3037345

3037346

3037347

3037348

3037349

3037350

3037354

3037355

3037356

3037357

3037358

3037359

3037360

3037366

3037367

3037368

3037371

3037372

3037373

3037374

3037375

3037376

3037379

3037380

3037381

3037382

3037383

3037384

3037411

3037412

44078_at

50942_at

50944_g_at

59960_at

8138091

A_23_P8539

GE481327

GE79747

GO:0001516

GO:0004806

GO:0005515

GO:0005654

GO:0005765

GO:0005886

GO:0006629

GO:0006640

GO:0006690

GO:0007405

GO:0010898

GO:0016020

GO:0016042

GO:0016298

GO:0016787

GO:0019369

GO:0022008

GO:0030154

GO:0046340

GO:0046872

GO:0047372

GO:0050727

GO:1901696

HMNXSV003008476

Hs.131899.0.A1_3p_at

Hs.131899.1.A1_3p_at

Hs.131899.1.A2_3p_a_at

Hs.131899.1.A2_3p_at

ILMN_1658885

PH_hs_0007851

TC07003349.hg

Participates

as a member of

Diacylglycerol lipase [plasma membrane] (Homo sapiens)

Inferred To

DAGLB [plasma membrane] (Bos taurus)

DAGLB [plasma membrane] (Canis familiaris)

DAGLB [plasma membrane] (Dictyostelium discoideum)

DAGLB [plasma membrane] (Gallus gallus)

DAGLB [plasma membrane] (Sus scrofa)

daglb [plasma membrane] (Danio rerio)

daglb [plasma membrane] (Xenopus tropicalis)

Daglb [plasma membrane] (Mus musculus)

Daglb [plasma membrane] (Rattus norvegicus)

Homologues of DAGLB [plasma membrane] (Dictyostelium discoideum)

dagl-2 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001136408.1, NP_631918.3

ZINC - World Drugs

DGLB_HUMAN

Guide to Pharmacology - Targets

1397

ENSEMBL

ENSP00000391171, ENSG00000164535, ENST00000425398, ENST00000297056, ENSP00000297056

OpenTargets

ENSG00000164535

ZINC - FDA approved

DGLB_HUMAN

ZINC - Substances

DGLB_HUMAN

ZINC target

Q8NCG7

PRO

Q8NCG7

IntEnz

3.1.1.116

GeneCards

DAGLB

HPA

ENSG00000164535-DAGLB

Pharos - Targets

Q8NCG7

ZINC - Predictions - Purchasable

DGLB_HUMAN

HMDB Protein

HMDBP07283

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92989 CLP1	1	CLP1 [nucleoplasm] (R-HSA-72017)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P21926 CD9	4	CD9 [platelet alpha granule membrane] (R-HSA-114585) CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779)	0.462	2