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PCF11 [nucleoplasm]
Stable Identifier
R-HSA-72019
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CF II - PCF11, Pre-mRNA cleavage complex II protein Pcf11
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Dengue Virus Infection (Homo sapiens)
Dengue Virus-Host Interactions (Homo sapiens)
NS5 interacts with Spliceosome (Homo sapiens)
NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
mRNA 3'-end cleavage factor [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
mRNA Polyadenylation (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Formation of the CF II complex (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
PP1 dephosphorylates RNA Pol II (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
RBBP6 activates CPSF complex (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Recruitment of other CPA components to pre-mRNA-bound CPA core (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Ub-K63-CPA complex [nucleoplasm] (Homo sapiens)
CF II:ATP [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
PCF11 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94913 PCF11
Gene Names
PCF11, KIAA0824
Chain
initiator methionine:1, chain:2-1555
Reference Genes
BioGPS Gene:51585 PCF11
COSMIC (genes):PCF11 PCF11
CTD Gene:51585 PCF11
dbSNP Gene:51585 PCF11
ENSEMBL:ENSG00000165494 PCF11
HGNC:30097 PCF11
KEGG:hsa:51585 PCF11
Monarch:51585 PCF11
NCBI Gene:51585 PCF11
OMIM:608876 PCF11
UCSC:O94913 PCF11
Reference Transcript
RefSeq:NM_015885.3 PCF11
Other Identifiers
11722295_at
11755004_a_at
16729585
203378_PM_at
203378_at
227622_PM_at
227622_at
3342524
3342526
3342527
3342528
3342529
3342530
3342531
3342532
3342535
3342538
3342539
3342540
3342541
3342543
3342544
3342545
3342546
3342547
3342552
3342554
3342556
3342557
3342559
3342560
3342561
3342562
3342563
3342565
3342566
3342567
3342568
41665_at
45661_at
51585
7942839
A_14_P118733
A_23_P116578
A_24_P835763
A_24_P932479
A_33_P3210139
GE53525
GE79955
GO:0000993
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005849
GO:0006369
GO:0006397
GO:0016071
GO:0031124
GO:0180010
HMNXSV003034086
HMNXSV003056130
Hs.123654.0.S2_3p_at
Hs.48752.0.A1_3p_at
ILMN_1798602
PH_hs_0006959
TC11000856.hg
Participates
as an input of
Formation of the CF II complex (Homo sapiens)
as a component of
CF II:ATP [nucleoplasm] (Homo sapiens)
CF II [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS
(Homo sapiens)
Integrator complex processes the 3' end of snRNA
(Homo sapiens)
Inferred To
pcf11 [nucleoplasm]
(Danio rerio)
pcf11 [nucleoplasm]
(Dictyostelium discoideum)
pcf11 [nucleoplasm]
(Xenopus tropicalis)
pcf-11 [nucleoplasm]
(Caenorhabditis elegans)
PCF11 [nucleoplasm]
(Bos taurus)
PCF11 [nucleoplasm]
(Canis familiaris)
PCF11 [nucleoplasm]
(Gallus gallus)
PCF11 [nucleoplasm]
(Saccharomyces cerevisiae)
PCF11 [nucleoplasm]
(Schizosaccharomyces pombe)
PCF11 [nucleoplasm]
(Sus scrofa)
Pcf11 [nucleoplasm]
(Drosophila melanogaster)
Pcf11 [nucleoplasm]
(Mus musculus)
Pcf11 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_056969.2
ENSEMBL
ENSP00000298281
,
ENSG00000165494
,
ENST00000298281
OpenTargets
ENSG00000165494
GeneCards
PCF11
HPA
ENSG00000165494-PCF11
PRO
O94913
Pharos - Targets
O94913
GlyGen
O94913
PDB
6WJH
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92989 CLP1
1
CLP1 [nucleoplasm]
(R-HSA-72017)
0.59
3
UniProt:Q9NXV6 CARF
0.527
3
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