Reactome | CPSF7 [nucleoplasm]

CPSF7 [nucleoplasm]

Stable Identifier

R-HSA-72012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CF I - 59 kDa subunit, Cleavage Factor I 59 kDa subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8N684 CPSF7

Gene Names

CPSF7

Chain

chain:1-471

Reference Genes

BioGPS Gene:79869 CPSF7

COSMIC (genes):CPSF7 CPSF7

CTD Gene:79869 CPSF7

dbSNP Gene:79869 CPSF7

ENSEMBL:ENSG00000149532 CPSF7

HGNC:30098 CPSF7

KEGG:hsa:79869 CPSF7

Monarch:79869 CPSF7

NCBI Gene:79869 CPSF7

UCSC:Q8N684 CPSF7

Reference Transcript

Participates

as a component of

CF I [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CPSF7 [cytosol]

Inferred To

CPSF7 [nucleoplasm] (Bos taurus)

CPSF7 [nucleoplasm] (Canis familiaris)

CPSF7 [nucleoplasm] (Gallus gallus)

CPSF7 [nucleoplasm] (Sus scrofa)

cpsf7 [nucleoplasm] (Xenopus tropicalis)

cfim-2 [nucleoplasm] (Caenorhabditis elegans)

Cpsf7 [nucleoplasm] (Mus musculus)

Cpsf7 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CPSF7 [nucleoplasm] (Dictyostelium discoideum)

cpsf6 [nucleoplasm] (Danio rerio)

Cpsf6 [nucleoplasm] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000340437, ENSP00000397203, ENST00000448745, ENST00000439958, ENSP00000378352, ENSP00000407394, ENSG00000149532, ENST00000394888, ENSP00000345412

OpenTargets

ENSG00000149532

GeneCards

CPSF7

HPA

ENSG00000149532-CPSF7

PRO

Q8N684

Pharos - Targets

Q8N684

GlyGen

Q8N684

PDB

3N9U

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.666	4
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.618	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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