q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

Stable Identifier
R-HSA-71130
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic dihydropteridine reductase (QDPR) catalyzes the reaction of q-dihydrobiopterin with NADH + H+to form tetrahydrobiopterin and NAD+. The enzyme is a homodimer (Lockyer et al. 1987; Su et al. 1993).

Literature References
PubMed ID Title Journal Year
3033643 Structure and expression of human dihydropteridine reductase.

Lockyer, J, Cook, RG, Milstien, S, Kaufman, S, Woo, SL, Ledley, FD

Proc Natl Acad Sci U S A 1987
8262916 The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue

Su, Y, Varughese, KI, Xuong, NH, Bray, TL, Roche, DJ, Whiteley, JM

J Biol Chem 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored