q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

Stable Identifier
R-HSA-71130
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
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Cytosolic dihydropteridine reductase (QDPR) catalyzes the reaction of q-dihydrobiopterin with NADH + H+to form tetrahydrobiopterin and NAD+. The enzyme is a homodimer (Lockyer et al. 1987; Su et al. 1993).
Literature References
PubMed ID Title Journal Year
8262916 The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue

Xuong, NH, Varughese, KI, Su, Y, Roche, DJ, Bray, TL, Whiteley, JM

J Biol Chem 1993
3033643 Structure and expression of human dihydropteridine reductase.

Woo, SL, Ledley, FD, Milstien, S, Kaufman, S, Lockyer, J, Cook, RG

Proc Natl Acad Sci U S A 1987
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Catalyst Activity

6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]

Physical Entity
QDPR dimer [cytosol] (Homo sapiens)
Activity
6,7-dihydropteridine reductase activity (GO:0004155)
Orthologous Events
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
Authored
D'Eustachio, P  (2003-06-24)
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