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THFPG [cytosol]
Stable Identifier
R-ALL-197969
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
THF-polyglutamate, tetrahydrofolyl-poly(glutamic acid) macromolecule
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Metabolism of folate and pterines (Bos taurus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Bos taurus)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)
THFPG [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Metabolism of folate and pterines (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)
THFPG [cytosol]
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Metabolism of folate and pterines (Canis familiaris)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Canis familiaris)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)
THFPG [cytosol]
Metabolism (Danio rerio)
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Danio rerio)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)
THFPG [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Metabolism of folate and pterines (Dictyostelium discoideum)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)
THFPG [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Metabolism of folate and pterines (Drosophila melanogaster)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Drosophila melanogaster)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)
THFPG [cytosol]
Metabolism (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Metabolism of folate and pterines (Gallus gallus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Gallus gallus)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Gallus gallus)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Gallus gallus)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Gallus gallus)
THFPG [cytosol]
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Homo sapiens)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)
THFPG [cytosol]
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Metabolism of folate and pterines (Mus musculus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Mus musculus)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)
THFPG [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Metabolism of folate and pterines (Plasmodium falciparum)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)
THFPG [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Metabolism of folate and pterines (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)
THFPG [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of folate and pterines (Saccharomyces cerevisiae)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)
THFPG [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of folate and pterines (Schizosaccharomyces pombe)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)
THFPG [cytosol]
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Metabolism of folate and pterines (Sus scrofa)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Sus scrofa)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)
THFPG [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Metabolism of folate and pterines (Xenopus tropicalis)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)
THFPG [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
THFPG [cytosol]
FPGS-2 transforms THF to THFPG (Xenopus tropicalis)
THFPG [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)
THFPG [cytosol]
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)
THFPG [cytosol]
External Reference Information
External Reference
tetrahydrofolyl-poly(glutamic acid) macromolecule [ChEBI:28624]
Participates
as an input of
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Saccharomyces cerevisiae)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Schizosaccharomyces pombe)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Gallus gallus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Canis familiaris)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Danio rerio)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Gallus gallus)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Drosophila melanogaster)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Schizosaccharomyces pombe)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)
as an output of
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Mus musculus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Gallus gallus)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Caenorhabditis elegans)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Schizosaccharomyces pombe)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Saccharomyces cerevisiae)
FPGS-2 transforms THF to THFPG (Homo sapiens)
FPGS-2 transforms THF to THFPG (Mus musculus)
FPGS-2 transforms THF to THFPG (Canis familiaris)
FPGS-2 transforms THF to THFPG (Bos taurus)
FPGS-2 transforms THF to THFPG (Sus scrofa)
FPGS-2 transforms THF to THFPG (Danio rerio)
FPGS-2 transforms THF to THFPG (Xenopus tropicalis)
FPGS-2 transforms THF to THFPG (Gallus gallus)
FPGS-2 transforms THF to THFPG (Drosophila melanogaster)
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
FPGS-2 transforms THF to THFPG (Dictyostelium discoideum)
FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)
FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
Other forms of this molecule
THFPG [mitochondrial matrix]
Cross References
COMPOUND
C03541
HMDB Metabolite
HMDB0006825
ZINC
000004098017
,
000004098016
,
000059066400
,
000008552070
,
000004098015
,
000004098014
,
000261499438
,
000008552069
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