The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).
Chuikov, S, Kurash, JK, Wilson, JR, Xiao, B, Justin, N, Ivanov, GS, McKinney, K, Tempst, P, Prives, C, Gamblin, SJ, Barlev, NA, Reinberg, D
Couture, JF, Collazo, E, Hauk, G, Trievel, RC
Bai, Q, Shen, Y, Yao, X, Wang, F, Du, Y, Wang, Q, Jin, N, Hai, J, Hu, T, Yang, J
© 2021 Reactome