SETD9 methylates TP53

Stable Identifier
R-HSA-6805730
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References
PubMed ID Title Journal Year
16415881 Structural basis for the methylation site specificity of SET7/9

Couture, JF, Hauk, G, Trievel, RC, Collazo, E

Nat. Struct. Mol. Biol. 2006
15525938 Regulation of p53 activity through lysine methylation

Kurash, JK, Reinberg, D, Gamblin, SJ, Wilson, JR, Prives, C, Xiao, B, Chuikov, S, Barlev, NA, Tempst, P, McKinney, K, Ivanov, GS, Justin, N

Nature 2004
21625555 Modeling a new water channel that allows SET9 to dimethylate p53

Yang, J, Wang, Q, Hai, J, Bai, Q, Du, Y, Jin, N, Hu, T, Wang, F, Yao, X, Shen, Y

PLoS ONE 2011
Participants
Participates
Catalyst Activity

lysine N-methyltransferase activity of SETD9 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!