SETD9 methylates TP53

Stable Identifier
R-HSA-6805730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SETD9 methylates TP53
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The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References
PubMed ID Title Journal Year
15525938 Regulation of p53 activity through lysine methylation

Chuikov, S, Kurash, JK, Wilson, JR, Xiao, B, Justin, N, Ivanov, GS, McKinney, K, Tempst, P, Prives, C, Gamblin, SJ, Barlev, NA, Reinberg, D

Nature 2004
16415881 Structural basis for the methylation site specificity of SET7/9

Couture, JF, Collazo, E, Hauk, G, Trievel, RC

Nat. Struct. Mol. Biol. 2006
21625555 Modeling a new water channel that allows SET9 to dimethylate p53

Bai, Q, Shen, Y, Yao, X, Wang, F, Du, Y, Wang, Q, Jin, N, Hai, J, Hu, T, Yang, J

PLoS ONE 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of SETD9 [nucleoplasm]
Physical Entity
SETD9 [nucleoplasm]
Activity
lysine N-methyltransferase activity (0016278)
Orthologous Events
SETD9 methylates TP53 (Bos taurus)
SETD9 methylates TP53 (Danio rerio)
SETD9 methylates TP53 (Sus scrofa)
SETD9 methylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-20)