Reactome | Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm]

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm]

Stable Identifier

R-HSA-6805731

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SETD9 methylates TP53 (Homo sapiens)
        
        Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
16415881	Structural basis for the methylation site specificity of SET7/9 Couture, JF, Collazo, E, Hauk, G, Trievel, RC	Nat. Struct. Mol. Biol.	2006
15525938	Regulation of p53 activity through lysine methylation Chuikov, S, Kurash, JK, Wilson, JR, Xiao, B, Justin, N, Ivanov, GS, McKinney, K, Tempst, P, Prives, C, Gamblin, SJ, Barlev, NA, Reinberg, D	Nature	2004
21625555	Modeling a new water channel that allows SET9 to dimethylate p53 Bai, Q, Shen, Y, Yao, X, Wang, F, Du, Y, Wang, Q, Jin, N, Hai, J, Hu, T, Yang, J	PLoS ONE	2011

Participants

components

x 4 Me1-K372,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)

Participates

as an output of

SETD9 methylates TP53 (Homo sapiens)

Inferred To

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Bos taurus)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Canis familiaris)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Danio rerio)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Drosophila melanogaster)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Mus musculus)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Rattus norvegicus)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Sus scrofa)

Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm] (Xenopus tropicalis)

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